COVID-19, host response treatment, and the need for political leadership

DS Fedson - Journal of Public Health Policy, 2021 - Springer
… Research on host response treatment Table 1 shows a research agenda for host response
treatment of COVID-19 and other pandemic diseases. If studies such as these are not …

Transcriptional and proteomic insights into the host response in fatal COVID-19 cases

M Wu, Y Chen, H Xia, C Wang… - Proceedings of the …, 2020 - National Acad Sciences
… To systematically identify biological pathways representative of the host tissue response
in COVID-19, we performed gene ontology (GO) enrichment analysis of significantly up- and …

The role of host genetics in the immune response to SARS‐CoV‐2 and COVID19 susceptibility and severity

IG Ovsyannikova, IH Haralambieva… - Immunological …, 2020 - Wiley Online Library
This article provides a review of studies evaluating the role of host (and viral) genetics (including
variation in HLA genes) in the immune response to coronaviruses, as well as the …

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

JF Bermejo-Martin, M González-Rivera, R Almansa… - Critical Care, 2020 - Springer
COVID-19 can course with respiratory and extrapulmonary … COVID-19 is characterized by a
dysregulated host response to this … severe COVID-19 and also to this dysregulated response. …

Analysis of genetic host response risk factors in severe COVID-19 patients

K Taylor, S Das, M Pearson, J Kozubek, M Pawlowski… - medRxiv, 2020 - medrxiv.org
COVID-19 patients has become available in the UK Biobank 7,8 , we are now able to
investigate the host response … patients hospitalized with severe COVID-19 and comparing them …

[HTML][HTML] Imbalanced host response to SARS-CoV-2 drives development of COVID-19

D Blanco-Melo, BE Nilsson-Payant, WC Liu, S Uhl… - Cell, 2020 - cell.com
response of SARS-CoV-2 with other respiratory viruses to identify transcriptional signatures
that may underlie COVID-19 … Despite virus replication, the host response to SARS-CoV-2 …

Characterisation of the blood RNA host response underpinning severity in COVID-19 patients

H Jackson, I Rivero Calle, C Broderick… - Scientific reports, 2022 - nature.com
… severity was characterised by an abundance of inflammatory immune response genes and
… to COVID-19 patients greatly alter the transcriptome. Our insights into COVID-19 severity …

A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood

DL Ng, AC Granados, YA Santos, V Servellita… - Science …, 2021 - science.org
… a distinct host response biosignature in patients with COVID-19 and an augmented response
in … utility of host response–based classifiers for SARS-CoV-2 infection. Here, we present a …

COVID-19: immunopathogenesis and Immunotherapeutics

L Yang, S Liu, J Liu, Z Zhang, X Wan… - Signal transduction and …, 2020 - nature.com
… With the unraveling of the relationship between immune responses and COVID-19, immune
… for COVID-19. In this review, we summarize the immune characteristics of COVID-19 and …

A dynamic immune response shapes COVID-19 progression

EZ Ong, YFZ Chan, WY Leong, NMY Lee… - Cell host & …, 2020 - cell.com
… of three COVID-19 cases and found that the early immune response in … for COVID-19. This
work may also guide future studies to illuminate COVID-19 pathogenesis and develop host-…