Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence
FMP Van Haren, C Page, JG Laffey, A Artigas… - Critical Care, 2020 - Springer
… Nebulised unfractionated heparin (UFH) has a strong scientific and biological rationale
and … potential, for COVID-19-induced acute respiratory distress syndrome (ARDS). COVID-19 …
and … potential, for COVID-19-induced acute respiratory distress syndrome (ARDS). COVID-19 …
Heparin-induced thrombocytopenia in COVID-19
P Lingamaneni, S Gonakoti, K Moturi… - … high impact case …, 2020 - journals.sagepub.com
… potential overdiagnosis of HIT in COVID-19 … all COVID-19 patients on heparin for indices
of HIT by performing the 4T score. We report a case of HIT in a patient with critical COVID-19 …
of HIT by performing the 4T score. We report a case of HIT in a patient with critical COVID-19 …
[HTML][HTML] Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing
L Jiang, T Zhang, H Lu, S Li, K Lv, A Tuffour… - Synthetic and Systems …, 2023 - Elsevier
… heparin in treating thrombosis and COVID-19 patients and the underlying mechanisms of
heparin's … Production of heparin and heparin mimetics via chemical synthesis, chemoenzymatic …
heparin's … Production of heparin and heparin mimetics via chemical synthesis, chemoenzymatic …
Heparin therapy improving hypoxia in COVID-19 patients–a case series
EM Negri, BM Piloto, LK Morinaga, CVP Jardim… - Frontiers in …, 2020 - frontiersin.org
… in COVID-19 and the potential response to early anticoagulation therapy. … COVID-19 patients,
in response to the anticoagulation, points to a potential role for systematic use of heparin in …
in response to the anticoagulation, points to a potential role for systematic use of heparin in …
[HTML][HTML] The challenges of diagnosing heparin‐induced thrombocytopenia in patients with COVID‐19
JE May, RC Siniard, M Marques - Research and practice in …, 2020 - ncbi.nlm.nih.gov
… the COVID‐19 population to determine the frequency of HIT, the frequency of nonpathogenic
anti‐PF4/heparin … HIT and COVID‐19 along with the potential for false‐positive EIA results. …
anti‐PF4/heparin … HIT and COVID‐19 along with the potential for false‐positive EIA results. …
The role of heparin in COVID-19: an update after two years of pandemics
M Mangiafico, A Caff, L Costanzo - Journal of Clinical Medicine, 2022 - mdpi.com
… Another intriguing potential therapeutic role of heparin in COVID-19 seems to be the inhibition
of heparanase, an endothelial glycocalyx-degrading enzyme that contributes to vascular …
of heparanase, an endothelial glycocalyx-degrading enzyme that contributes to vascular …
Heparin-induced thrombocytopenia is associated with a high risk of mortality in critical COVID-19 patients receiving heparin-involved treatment
X Liu, X Zhang, Y Xiao, T Gao, G Wang, Z Wang… - MedRxiv, 2020 - medrxiv.org
… It is essential to investigate the clinical characteristics of COVID-19 and uncover potential …
in severe COVID-19 patients who received heparin-involved therapy, or were heparin-naïve (…
in severe COVID-19 patients who received heparin-involved therapy, or were heparin-naïve (…
Heparin beyond anti-coagulation
D Chen - Current Research in Translational Medicine, 2021 - Elsevier
… heparin, to address the unmet clinical needs of severe illness including coronavirus disease
2019 (COVID-19… the therapeutic potentials of existing heparin medications beyond anti-…
2019 (COVID-19… the therapeutic potentials of existing heparin medications beyond anti-…
Differentiating biochemical from clinical heparin resistance in COVID-19
T Lisman, J Thachil - Journal of thrombosis and thrombolysis, 2020 - Springer
… preferred when monitoring heparins in COVID-19 patients. … COVID-19 patients are truly
resistant to the anticoagulant action of heparins, or whether the high baseline hemostatic potential…
resistant to the anticoagulant action of heparins, or whether the high baseline hemostatic potential…
Heparin in COVID-19 patients is associated with reduced in-hospital mortality: the multicenter Italian CORIST study
A Di Castelnuovo, S Costanzo… - Thrombosis and …, 2021 - thieme-connect.com
… in COVID-19 patients is if therapeutic doses of heparin are … Probably the hemorrhagic potential
of high doses of heparin, … with COVID-19, may partly overcome the potential benefit of full …
of high doses of heparin, … with COVID-19, may partly overcome the potential benefit of full …