Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence

FMP Van Haren, C Page, JG Laffey, A Artigas… - Critical Care, 2020 - Springer
… Nebulised unfractionated heparin (UFH) has a strong scientific and biological rationale
and … potential, for COVID-19-induced acute respiratory distress syndrome (ARDS). COVID-19

Heparin-induced thrombocytopenia in COVID-19

P Lingamaneni, S Gonakoti, K Moturi… - … high impact case …, 2020 - journals.sagepub.com
potential overdiagnosis of HIT in COVID-19 … all COVID-19 patients on heparin for indices
of HIT by performing the 4T score. We report a case of HIT in a patient with critical COVID-19

[HTML][HTML] Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing

L Jiang, T Zhang, H Lu, S Li, K Lv, A Tuffour… - Synthetic and Systems …, 2023 - Elsevier
heparin in treating thrombosis and COVID-19 patients and the underlying mechanisms of
heparin's … Production of heparin and heparin mimetics via chemical synthesis, chemoenzymatic …

Heparin therapy improving hypoxia in COVID-19 patients–a case series

EM Negri, BM Piloto, LK Morinaga, CVP Jardim… - Frontiers in …, 2020 - frontiersin.org
… in COVID-19 and the potential response to early anticoagulation therapy. … COVID-19 patients,
in response to the anticoagulation, points to a potential role for systematic use of heparin in …

[HTML][HTML] The challenges of diagnosing heparin‐induced thrombocytopenia in patients with COVID19

JE May, RC Siniard, M Marques - Research and practice in …, 2020 - ncbi.nlm.nih.gov
… the COVID19 population to determine the frequency of HIT, the frequency of nonpathogenic
anti‐PF4/heparin … HIT and COVID19 along with the potential for false‐positive EIA results. …

The role of heparin in COVID-19: an update after two years of pandemics

M Mangiafico, A Caff, L Costanzo - Journal of Clinical Medicine, 2022 - mdpi.com
… Another intriguing potential therapeutic role of heparin in COVID-19 seems to be the inhibition
of heparanase, an endothelial glycocalyx-degrading enzyme that contributes to vascular …

Heparin-induced thrombocytopenia is associated with a high risk of mortality in critical COVID-19 patients receiving heparin-involved treatment

X Liu, X Zhang, Y Xiao, T Gao, G Wang, Z Wang… - MedRxiv, 2020 - medrxiv.org
… It is essential to investigate the clinical characteristics of COVID-19 and uncover potential
in severe COVID-19 patients who received heparin-involved therapy, or were heparin-naïve (…

Heparin beyond anti-coagulation

D Chen - Current Research in Translational Medicine, 2021 - Elsevier
heparin, to address the unmet clinical needs of severe illness including coronavirus disease
2019 (COVID-19… the therapeutic potentials of existing heparin medications beyond anti-…

Differentiating biochemical from clinical heparin resistance in COVID-19

T Lisman, J Thachil - Journal of thrombosis and thrombolysis, 2020 - Springer
… preferred when monitoring heparins in COVID-19 patients. … COVID-19 patients are truly
resistant to the anticoagulant action of heparins, or whether the high baseline hemostatic potential

Heparin in COVID-19 patients is associated with reduced in-hospital mortality: the multicenter Italian CORIST study

A Di Castelnuovo, S Costanzo… - Thrombosis and …, 2021 - thieme-connect.com
… in COVID-19 patients is if therapeutic doses of heparin are … Probably the hemorrhagic potential
of high doses of heparin, … with COVID-19, may partly overcome the potential benefit of full …