Tocilizumab and COVID-19: timing of administration and efficacy

E Abidi, WS El Nekidy, E Alefishat, N Rahman… - Frontiers in …, 2022 - frontiersin.org
… and efficacy of using tocilizumab as a drug of preference to treat COVID-19 patients. We …
behind using tocilizumab, as well as differences in its use based on the COVID-19 stage and…

Tocilizumab administration for the treatment of hospitalized patients with COVID19: a systematic review and meta‐analysis

C Kyriakopoulos, G Ntritsos, A Gogali, H Milionis… - …, 2021 - Wiley Online Library
coronavirus disease 2019 (COVID-19). Our aim was to evaluate the efficacy of tocilizumab in
the management of hospitalized COVID-19 … studies of tocilizumab in hospitalized COVID-19

Impact of tocilizumab administration on mortality in severe COVID-19

A Tsai, O Diawara, RG Nahass, L Brunetti - Scientific reports, 2020 - nature.com
… We identified a total of 84 patients who received tocilizumab and 190 patients who were
treated without the use of tocilizumab as part of COVID-19 management in our hospital. After the …

Tocilizumab in patients with severe COVID-19: a retrospective cohort study

G Guaraldi, M Meschiari, A Cozzi-Lepri… - The Lancet …, 2020 - thelancet.com
… In our multicentre, retrospective study of 544 patients with severe COVID-19 pneumonia, the
use of tocilizumab administered either intravenously or subcutaneously was associated with …

Tocilizumab for treatment of severe COVID-19 patients: preliminary results from SMAtteo COvid19 REgistry (SMACORE)

…, R Bruno, COVID IRCCS San Matteo Pavia Task Force - Microorganisms, 2020 - mdpi.com
… In this study, we report preliminary data from our experience with TCZ administration in
COVID-19 patients hospitalized in a Regional Referral Hospital in the Lombardy region, Italy. …

Does timing matter on tocilizumab administration? Clinical, analytical and radiological outcomes in COVID-19

RM Diaz, MAA García, FJT Muñoz… - European Journal of …, 2022 - ejhp.bmj.com
Administration of tocilizumab was not associated with relevant … of administration of
tocilizumab in patients with COVID-19 pneumonia. A strategy involving tocilizumab administration

Timely administration of tocilizumab improves outcome of hospitalized COVID-19 patients

A Rutgers, PE Westerweel, B van der Holt, S Postma… - Plos one, 2022 - journals.plos.org
… the IL-6 inhibitor tocilizumab, we hypothesized that early (pre-emptive) intervention with
tocilizumab might beneficially alter the course of Covid-19. We postulated that tocilizumab would …

Tocilizumab in the management of COVID-19: a preliminary report

M Li, EJ Yoo, M Baram, M McArthur, C Skeehan… - The American Journal of …, 2021 - Elsevier
… On this basis, physicians at our hospitals have administered Tocilizumab to COVID-19
patients with severe respiratory impairment off-label and outside of a clinical trial hoping to …

[HTML][HTML] Early administration of tocilizumab in hospitalized COVID-19 patients with elevated inflammatory markers; COVIDSTORM—a prospective, randomized, single …

N Broman, T Feuth, T Vuorinen, M Valtonen… - Clinical Microbiology …, 2022 - Elsevier
COVID-19, hypoxemia, and at least two of four markedly elevated markers of inflammation
(interleukin-6, C-reactive protein, ferritin, and/or D-dimer) were randomized for tocilizumab (…

[HTML][HTML] Rationale and evidence on the use of tocilizumab in COVID-19: a systematic review

A Cortegiani, M Ippolito, M Greco, V Granone, A Protti… - Pulmonology, 2021 - Elsevier
… .63, 64 The World Health Organization (WHO) 65 and the Infectious Diseases Society of
America (IDSA) 66 both recommend that tocilizumab only be administered within the context of …