… Because new base editors significantly reduce unintended editing in the … base editors,
assess their technical advantages and limitations, and discuss their broad applications in basic …

… While homology-directed repair (HDR) coupled with Cas9 nuclease … base-editing systems
present a useful orthogonal strategy to engineer nucleotide substitutions. Base editing relies …

… cytosine and adenosine base editors and more recently guanosine base editors. Because …
Here, we provide a detailed update on DNA base editors. While base editing has widely been …

… Base-editors to create single and multiple nucleotide modifications in cells. Here we
review different base editing … Bases 5–7 of the classical guanine base editor is the CGBE-SpCas9 …

… a donor DNA template mediated by repair of CRISPR/Cas9-induced DNA double strand …
A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice. …

… Our report provides the first solid example showing that the CRISPR/Cas9-mediated base-editing
system is a tremendously powerful tool for improvement of watermelon varieties. …

… To test base editor-mediated base mutation in vivo, we chose a third-generation base
editor (BE3) that consists of the rat cytidine deaminase rAPOBEC1, Cas9 nickase (nCas9) and …

… of CRISPR-mediated base editing for gene disruption studies. We show that CRISPR base
editors … This system relies on the ability of CRISPR-Cas9-dependent base editors to precisely …

… oil palm via base editing technology. Precise genome editing via base editing approach can
… in oil palm provides a platform for developing the base editing technology. Here, we briefly …

… of Cas9-independent off-targeting and point to TC motifs as activity hotspots of the cytidine
deaminase used. We anticipate that CRISPR-mediated base editing is the … and gene editing. …