[HTML][HTML] Diversity of CRISPR-Cas immune systems and molecular machines

R Barrangou - Genome biology, 2015 - Springer
… various molecular machines to expand the molecular biology … , the diversity of CRISPR-Cas
systems will predictably further … , and valuable Cas molecular machines might be unearthed …

DNA origami‐based single‐molecule CRISPR machines for spatially resolved searching

Y Hao, M Li, Q Zhang, J Shi, J Li, Q Li… - Angewandte Chemie …, 2022 - Wiley Online Library
… In addition, previous studies have shown that CRISPR … of CRISPR/Cas 18 and single-molecule
analysis. In this study, we develop DNA origami-based CRISPR molecular machines with …

A decade of discovery: CRISPR functions and applications

R Barrangou, P Horvath - Nature microbiology, 2017 - nature.com
… of CRISPRCas as adaptive immune systems in bacteria. In just a decade, the characterization
of CRISPRCas … their environment, and CRISPR-based molecular machines have been …

CRISPR-Cas: adapting to change

SA Jackson, RE McKenzie, RD Fagerlund, SN Kieper… - Science, 2017 - science.org
… regularly interspaced short palindromic repeats and associated proteins (CRISPR-Cas).
This molecular machinery can recognize and remember foreign nucleic acids by capturing and …

Engineering molecular machines for the control of cellular functions for diagnostics and therapeutics

A Zamat, L Zhu, Y Wang - Advanced Functional Materials, 2020 - Wiley Online Library
The utilization of live cells as therapeutic materials provides controllability and complexity
unmatched by small molecules and biologic agents. Recent advancements have shown that …

Molecular mechanisms of CRISPR-Cas immunity in bacteria

PM Nussenzweig, LA Marraffini - Annual review of genetics, 2020 - annualreviews.org
… the targeting machinery to … molecular mechanisms used by different CRISPR-Cas systems
to execute these three phases of immunity. Figure 1 The different phases of the CRISPR-Cas

Molecular mechanisms of CRISPRCas spacer acquisition

J McGinn, LA Marraffini - Nature Reviews Microbiology, 2019 - nature.com
CRISPRCas immune response. In this Progress article, we review recent studies that have
advanced our understanding of the molecular … two phases of CRISPR immunity that ensures …

The next generation of CRISPRCas technologies and applications

A Pickar-Oliver, CA Gersbach - Nature reviews Molecular cell biology, 2019 - nature.com
… In this Review, we discuss recent advances in CRISPRCas tools for gene editing and
epigenetic modulation, before describing a diverse range of new CRISPRCas functions. We …

Development of CRISPR-Cas systems for genome editing and beyond

F Zhang - Quarterly Reviews of Biophysics, 2019 - cambridge.org
CRISPR-Cas9 for genome editing within the broader context of the field and discuss our
work to discover novel Cas effectors and develop them into additional molecularCRISPR-Cas

Recent advances in molecular machines based on toehold‐mediated strand displacement reaction

Y Guo, B Wei, S Xiao, D Yao, H Li, H Xu… - Quantitative …, 2017 - Wiley Online Library
… Thereafter, we review the recent progresses in DNA complex circuit, the assembly of AuNPs
driven by DNA molecular machines, and the detection of single nucleotide polymorphism (…