Recent trends in CRISPR-Cas system: genome, epigenome, and transcriptome editing and CRISPR delivery systems

T Bae, JW Hur, D Kim, JK Hur - Genes & genomics, 2019 - Springer
… of CRISPR technology enabled genome editing to single base precision. Then, we discuss
the CRISPR based … regulation, epigenome editing, and RNA editing. Finally, we review the …

CRISPR technologies for genome, epigenome and transcriptome editing

L Villiger, J Joung, L Koblan, J Weissman… - … Reviews Molecular Cell …, 2024 - nature.com
… Our ability to edit genomes lags behind our capacity to sequence them, but the growing
understanding of CRISPR biology and its application to genome, epigenome and transcriptome

Mini review: genome and transcriptome editing using CRISPR-cas systems for haematological malignancy gene therapy

EK Elliott, LM Haupt, LR Griffiths - Transgenic Research, 2021 - Springer
… of existing CRISPR-Cas systems, along with new Cas effectors for transcriptome or RNA …
We also address the current diagnostic and therapeutic potential of CRISPR-Cas systems …

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors

J Grünewald, R Zhou, SP Garcia, S Iyer, CA Lareau… - Nature, 2019 - nature.com
… in editing efficiency. Finally, we show that an adenine base editor 7 can also induce
transcriptome-wide RNA edits… These results have implications for the use of base editors in both …

Genome and transcriptome engineering by compact and versatile CRISPR-Cas systems

G Aquino-Jarquin - Drug Discovery Today, 2023 - Elsevier
… the clinical utility of genome editing. Because CRISPR-Cas genome editing tools are prone
to errors, the newly developed CRISPR effectors require extensive characterization to be …

CRISPR–Cas13 precision transcriptome engineering in cancer

JT Granados-Riveron, G Aquino-Jarquin - Cancer research, 2018 - AACR
… Accordingly, RNA editing has been associated with tumorigenesis, by either … editing of
tumor-promoting genes or by transcriptome scale changes (34). Thus, precise nucleic acid editing

Comparative transcriptome and metabolome analyses of wild and mutant Oujiang color common carp through editing SCARB1 gene by CRISPR/Cas technology

NH Kanika, J Ke, RN Mandal, J Wang, C Wang - Aquaculture, 2023 - Elsevier
… In this study, skin transcriptome and blood metabolites were conducted in the fishes of
wild-type whole red, mutant-type whole red, and mutant-type whole white colorations to identify …

[HTML][HTML] Transcriptome engineering with RNA-targeting type VI-D CRISPR effectors

S Konermann, P Lotfy, NJ Brideau, J Oki… - Cell, 2018 - cell.com
… Our results present CasRx as a programmable RNA-binding module for efficient targeting
of cellular RNA, enabling a general platform for transcriptome engineering and future …

[HTML][HTML] Cas13d: a new molecular scissor for transcriptome engineering

R Gupta, A Ghosh, R Chakravarti, R Singh… - Frontiers in Cell and …, 2022 - frontiersin.org
… the Type VI CRISPR Cas system which has brought a new role to CRISPR to edit and target
… a gold standard in transcriptome editing and application beyond RNA editing with salutary …

Base editing: precision chemistry on the genome and transcriptome of living cells

HA Rees, DR Liu - Nature reviews genetics, 2018 - nature.com
… RNA-guided programmable nucleases from CRISPR systems generate precise breaks in …
Base editing is a newer genome-editing approach that uses components from CRISPR