… limb generally have poor outcomes. Human skeletal muscle contains both multipotent stem
cells and progenitor cells … bone marrow-derived progenitor cells into CLI limbs show positive …

… Advances in regenerative medicine have enabled the development of cell-based therapies
that promote the formation of new blood vessels. Particularly, mesenchymal stem cells (MSCs…

… (TcO 2 ) in cell therapy and standard care for critical limb ischemia. Subgroup analyses of
bone marrow stem cells (BMSCs) versus peripheral blood stem cells (PBSCs). Squares …

… that contribute to angiogenesis and/or vasculogenesis in ischemic tissue. Since then, …
of stem and progenitor cell types, delivered locally into ischemic tissue, to reduce ischemic …

… ) is chronic vascular disease that causes impaired circulation to the lower extremities [1, 2].
A subset of PAD patients has critical limb ischemia (… Critical limb ischemia caused by tissue …

… or impossibility to adapt to the need for increased blood flow are critical points through
which we investigate selective recruitment of stem and progenitor cells to the ischemic limb. …

… As far back as 2004, we first showed that these cells express the stem/progenitor cell marker
CD34 and display strong angiogenic properties in vitro as well as in vivo in an experimental …

… Table 2: Clinical trials using stem cells for treatment of critical limb ischemia. … Type of cells
… [120] AT Hirsch, “Critical limb ischemia and stem cell research: anchoring hope with informed …

… This review provides an overview of the potential role of MSC-based therapy for critical limb
ischemia (CLI), the comparison of MSC cellular therapy with angiogenesis gene therapy in …

… acute limb ischemia (a sudden process of severe limb hypoperfusion), as CLI occurs in a
chronic … Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into …