Pathogenesis of multiple sclerosis: a critical reappraisal

CM Poser - Acta neuropathologica, 1986 - Springer
… The pathogenesis of multiple sclerosis remains a dilemma despite many years of study. Evi…
On the other hand, the well-documented facts that multiple sclerosis plaques are invariably …

[HTML][HTML] Vitamin D supplementation in multiple sclerosis: a critical analysis of potentials and threats

J Feige, T Moser, L Bieler, K Schwenker, L Hauer… - Nutrients, 2020 - mdpi.com
Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative …
Here, we review the current understanding of the molecular effects of vitamin D beyond calcium …

Critical review: assessment of interferon-β immunogenicity in multiple sclerosis

K Bendtzen - Journal of Interferon & Cytokine Research, 2010 - liebertpub.com
This review discusses type I interferon (IFN) immunogenicity with focus on methods of detection
of anti-IFN antibodies in patients treated with human recombinant IFN-β. Pitfalls involved …

The increasing incidence and prevalence of female multiple sclerosis—a critical analysis of potential environmental factors

J Sellner, J Kraus, A Awad, R Milo, B Hemmer… - … reviews, 2011 - Elsevier
Multiple sclerosis (MS) is the most common acquired … ► It is hypothesized that multiple
sclerosis (MS) is a multifactorial … This article critically discusses the potential interplay of …

Oral drugs in multiple sclerosis therapy: an overview and a critical appraisal

E D'Amico, C Leone, C Caserta… - Expert review of …, 2015 - Taylor & Francis
Multiple sclerosis (MS) is characterized by demyelination and axonal loss that results in
progressive disability. Recent advances in understanding the immune pathogenesis of MS …

Critical appraisal of animal models of multiple sclerosis

D Baker, W Gerritsen, J Rundle… - Multiple Sclerosis …, 2011 - journals.sagepub.com
… disorders in laboratory animals that is used to model multiple sclerosis (MS). However, few
agents … The use of EAE is critically appraised with the aim of provoking thought, improving …

Critical appraisal of the role of fingolimod in the treatment of multiple sclerosis

C Warnke, O Stüve, HP Hartung… - Neuropsychiatric …, 2011 - Taylor & Francis
… This review summarizes Phase III clinical trial data available for fingolimod. The main … the
first oral compound available for treatment of multiple sclerosis (MS) and just recently approved …

The therapy of multiple sclerosis with immune-modulating or immunosuppressive drug: A critical evaluation based upon evidence based parameters and published …

M Clerico, C Rivoiro, G Contessa, D Viglietti… - Clinical neurology and …, 2008 - Elsevier
… are available for treatment of multiple sclerosis (MS). Interferons… This article aimed to review
all the clinical trials on immune-… Aim of this review is to give a critical reading of the published …

Advances in the treatment of relapsing—remitting multiple sclerosiscritical appraisal of fingolimod

C Gasperini, S Ruggieri, CR Mancinelli… - … and Clinical Risk …, 2013 - Taylor & Francis
… Citation12 In a phase IIb study, 257 patients with multiple sclerosis were enrolled to receive
three different doses of BG-12 or placebo. Citation13 Compared with placebo, BG-12 at 240 …

[HTML][HTML] … Review of the Role of the Cannabinoid Compounds Δ9-Tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD) and their Combination in Multiple Sclerosis …

É Jones, S Vlachou - Molecules, 2020 - mdpi.com
… to further our understanding of the role of cannabinoids in multiple sclerosis treatment. … well
as the research priorities ahead, a critical analysis of the literature is presented in this review. …