… of beta-lactam antibiotics is preferable in critically ill patients. No significant difference between
these two dosing strategies in terms of patient … numbers of heterogeneous patient groups. …

… critically ill patients and beta-lactams are the most common antibiotic class used. Critically ill
patient’s … factors lead to altered pharmacokinetics and pharmacodynamics of beta-lactams. …

… in critically ill patients with septic shock. … The β-lactam antibiotics, because of their large
antimicrobial spectrum and low toxicity, are among the first-line therapies for critically ill patients, …

… There is a growing body of literature in adult patients demonstrating that physiological
alterations occurring in critically ill patients may limit our ability to optimally dose beta-lactam …

… In this analysis, we found no significant pooled effect of TDM-guided dosing of beta-lactams
on all-cause mortality in critically ill patients with suspected or proven sepsis. TDM-guided …

… Given the strong possibility that many critically ill patients receive inadequate β-lactam …
in the critically ill in whom ARC is suspected, to guide either the application of β-lactam TDM …

… of critically ill patients has been observed with these strategies ( 16–18 ). With standard dosing
in critically ill patients, at least 30-fold variation in beta-lactam … Beta-lactam concentrations …

… Being small hydrophilic molecules, beta-lactams are likely to … in critically ill patients. This
article aims to describe the current clinical scenario for beta-lactam dosing in critically ill patients …

… Emerging data support the use of beta-lactam therapeutic … variability of beta-lactams in the
critically ill and to discuss the … to improve beta-lactam dosing in critically ill patients. Moreover…

… non-critically ill patients. In this context, the unpredictability of critical care patients’ exposure
to beta-lactam … for an individualization of the beta-lactam dose in critically ill patients [14, 15]. …