… gene regions that pass genome-wide significance, providing strong evidence for 144 genes.
… In total, we provide evidence for 200 gene regions confirming that CD is truly multifactorial …

… in the genetic susceptibility to Crohn's disease (CD). These loci encode genes involved in
a … Although there have been no known genes or CpG islands described within this region, …

… 51) that is located in this region, was the first Crohn disease gene to be identified by positional
cloning 52 . Three coding variants, R702W, G908R and 1007fsInsC, originally known as …

Seventy-five years after the initial characterization of Crohn's disease (CD), much remains
obscure about its etiology. The authors sought to evaluate the incidence trends of the last 25 …

… association with the disease (P<2×10 −7 ) and contains the cytokine gene cluster. This … of
the cytokine region in 5q31 confers susceptibility to Crohn disease. However, genetic evidence …

… We provide evidence in support of this hypothesis by demonstrating that genetic variants in
the CD-associated region differentially regulate the expression levels of PTGER4, the closest …

… disease susceptibility. Here, we review the history of gene-mapping studies of Crohn's
disease, … aimed at identifying the regions of the genome that contribute to Crohn's disease risk. …

… We sought first to study genetic variants from the 5q31 cytokine gene cluster in a British IBD
cohort. This region contains a cluster of immunoregulatory cytokines potentially important in …

… Crohn disease is a chronic, inflammatory disease of the … associated with susceptibility to
Crohn disease, as indicated by … with Crohn disease, but the pathogenic lesion in the region has …

… the 5.3-kb region described above, inclusively, which also comprised OR2B11 (Supplementary
Table 2 online). Overall, we selected 16 Crohn's disease … within the region and identify all …