… Asp, the resulting Asp490 might form a salt bridge with the neighboring conserved … cryo-EM
structure of human ABCB11 with an ATP-free and inward-facing conformation. This structure …

… Here we present cryo-electron microscopy structures of human NTCP in complexes with …
that serves as the transport pathway for bile salts, and exposes key determinant residues for …

… from bile acid overload, preventing atherosclerosis, and inhibiting macrophage inflammation
due to its critical role in bile acid sensitization. Thus, elucidation of structural characteristics …

… Presented here are the cryo-EM structures of MNV-1 in the presence of bile salts (∼3 Å)
and the receptor CD300lf (∼8 Å). Surprisingly, bile salts cause the rotation and contraction of …

… We determined a 2.9 Å resolution cryo-EM structure of nanodisc-reconstituted NTCP bound
to NTCP_Fab12, a Fab-binding nanobody and 100 μM GCDC (Fig. 1c, d; Supplementary …

… Here we report the cryo-electron microscopy structures of human, … Moreover, the cryo-electron
microscopy structure of human … Together, our findings provide a structural framework for …

… We report the cryo-EM structure of glibenclamide-bound human BSEP in nanodiscs, … the
reduced uptake of bile salts. We further report two high-resolution structures of BSEP trapped in …

… atomic resolution cryo-electron microscopy (cryo-EM) structure of … On the basis of previous
results, we show here that bile salts … Here, we present the near-atomic cryo-EM structure of the …

… of bile acids and is a signalling hub in the liver–bile acid–microbiota–metabolism axis 1,2,3 .
Here we report the cryo-electron microscopy structures … semisynthesized bile acid derivative …

… Again, this model agrees well with the cryo-EM structure within the resolution at which
cryo-EM data were presented. Notably, an overall structural … cryo-EM cryo electron microscopy …