… diet, apigenin lowered the number of high multiplicity ACF (HMACF >4 aberrant crypts/focus)
by 57% (P < 0.05), while naringenin … Both apigenin and naringenin increased apoptosis of …

… peak stage of aberrant crypt formation. Although hesperidin and nobiletin did not appear
to be chemoprotective in our study, other studies had shown potential health benefits of those …

… that apigenin and naringenin reduce the number of high multiplicity aberrant crypt foci (HMACF)
in … , specifically in the early stages, by first determining the mechanisms of apigenin and …

… stages would be beneficial toward a better understanding of the ameliorative effect of naringenin
… on the luminal surface and in the upper crypts in noncolitic control mice. Claudin-3 was …

… analogs for 48 h and then cell-cycle phases were monitored … 2) apigenin prevented
carcinogen-induced aberrant crypt foci … the apigenin analogs tested except myricetin and …

… In isolated rat colonic crypts, mucosal addition of naringenin (… Naringenin could increase
intracellular cAMP content and … chamber mounted on the stage with immersing lens microscopy …

… crypts (arrowhead) are observed around the aberrant crypts (arrow). c Hyperpigmented aberrant
crypts indicate the initial stage of … Foci identified with three (b) and 13 (d) aberrant crypts …

… Apigenin failed to inhibit adenoma formation in the APC MIN+ (MIN, multiple intestinal neoplasia)
mice models, but it showed reduced aberrant crypt … at an early stage of tumourigenesis. …

… movement up to the apex of the crypt and, hence, normal dif… or more stages in the normal
epithelia–adenoma–carcinoma … 50 µM apigenin and 1µM hesperidin and naringin were able …

… been developed to improve naringenin bioavailability. We conclude that naringenin should
be … in triggering cell cycle arrest, including both G1 and G2 phases of the cell cycle. Notably, …