… to the conclusion that TGF-α expression is differentially regulated and the presence of
elevated levels of TGF-α appears to be crucial or specific to late stages of colon carcinogenesis. …

… crypt foci (ACF) have been identified on the colonic mucosal surface of rodents treated with
colon carcinogens and … In that work, a group of large ACF, called ‘stage I abnormality crypts’ …

… to identify modulators of colon carcinogenesis, to identify the … cell death induced by a colon
carcinogen such as DMH or … crypt multiplicity, presumably representing advanced stages …

… stages for colon carcinogenesis in Apc Min/+ mouse, and the Apc Min/+ mouse is regarded
as a good model to study multistage colon carcinogenesis. … in the colonic crypts differentiate …

… at the promotion stage of chemically induced colon cancer in … Excised colons were evaluated
for aberrant crypt foci (ACF) … multiplicity ACF (HMACF >4 aberrant crypts/focus) by 57% (P < …

… proliferation in the colonic crypt represents the earliest recognizable stage in this sequence.
… , the ACF assay has become a useful tool to detect colon carcinogens in the diet [90], and to …

… In the present study, to determine if β-catenin signaling is involved in the initial stage of colon
carcinogenesis, mutational analysis of the β-catenin gene and immunohistochemistry forβ-…

… of the steps involved in colon carcinogenesis. The relevant … cell per crypt, although a small
number of stem cells per crypt … -stage model, ie, a model postulating two preinitiation stages…

… Alterations in PKC isozyme levels also played a role in colon carcinogenesis[48-50]. Elevated
… P-cadherin was aberrantly expressed at the earliest stage of aberrant crypt formation, …

… cells within the colonic crypts. The … to colon carcinogenesis via its effects on colonocyte
kinetics. Our observations in a murine model of colon cancer are focused on the very early stages …