Divergence of Protein Kinase A Catalytic Subunits in Cryptococcus neoformans and Cryptococcus gattii Illustrates Evolutionary Reconfiguration of a Signaling …

JK Hicks, J Heitman - Eukaryotic Cell, 2007 - Am Soc Microbiol
Protein kinase A catalytic and regulatory subunits interact in … First, we found that the protein
kinase A regulatory subunit … the catalytic and regulatory subunits of protein kinase A or in the …

[HTML][HTML] Transcriptional regulation by protein kinase A in Cryptococcus neoformans

G Hu, BR Steen, T Lian, AP Sham, N Tam… - PLoS …, 2007 - journals.plos.org
protein kinase A (PKA) is known to reduce capsule size and attenuate virulence in the
fungal pathogen Cryptococcus neoformans. … expression of ribosomal protein genes, genes …

[HTML][HTML] Interaction of Cryptococcus neoformans Rim101 and Protein Kinase A Regulates Capsule

TR O'Meara, D Norton, MS Price, C Hay… - PLoS …, 2010 - journals.plos.org
Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within
various tissues … Cryptococcus neoformans strains used in this study are listed in Table 1. All C. …

[HTML][HTML] The cAMP/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans

M Caza, JW Kronstad - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
… For instance, protein kinase A (PKA) in the human pathogen Cryptococcus neoformans plays
a … Saccharomyces cerevisiae to provide a foundation for understanding the pathway in C. …

Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans

CA D'Souza, JA Alspaugh, C Yue… - … and cellular biology, 2001 - Am Soc Microbiol
Cryptococcus neoformans is an opportunistic fungal … (cAMP)-dependent protein kinase
catalytic subunit was identified … The PKR1 gene encoding the protein kinase A (PKA) regulatory …

The cAMP/Protein Kinase A Pathway and Virulence in Cryptococcus neoformans

JW Kronstad, G Hu, J Choi - Mycobiology, 2011 - Taylor & Francis
… One of these pathways, the cAMP/protein kinase A (PKA) … in the basidiomycete pathogen
Cryptococcus neoformans. This … Many AIDS patients acquire cryptococcosis and the resulting …

Signalling pathways in the pathogenesis of Cryptococcus

L Kozubowski, SC Lee, J Heitman - Cellular microbiology, 2009 - Wiley Online Library
… the protein kinase A/cyclic AMP (cAMP), protein kinase C (PKC)/mitogen-activated protein
kinase (… The human pathogenic basidiomycetous fungus Cryptococcus neoformans deploys …

Ssk2 Mitogen-Activated Protein Kinase Kinase Kinase Governs Divergent Patterns of the Stress-Activated Hog1 Signaling Pathway in Cryptococcus neoformans

YS Bahn, S Geunes-Boyer, J Heitman - Eukaryotic cell, 2007 - Am Soc Microbiol
… p38/Hog1 mitogen-activated protein kinase (MAPK) pathway is … a majority of clinical
Cryptococcus neoformans serotype A and … upstream of the MAPKK Pbs2 and the MAPK Hog1 in …

[HTML][HTML] Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A

JMH Geddes, D Croll, M Caza, N Stoynov, LJ Foster… - BMC microbiology, 2015 - Springer
… The pathogenic yeast Cryptococcus neoformans causes life-… protein kinase A (PKA)
signal transduction pathway regulates the production of extracellular virulence factors in C

Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C‐α activation

A Jong, CH Wu, NV Prasadarao… - Cellular …, 2008 - Wiley Online Library
… In this report, we demonstrated that C. neoformans invasion of HBMEC was blocked in
the presence of G109203X, a protein kinase C (PKC) inhibitor, and by overexpression of a …