PAK Kinases Ste20 and Pak1 Govern Cell Polarity at Different Stages of Mating in Cryptococcus neoformans

CB Nichols, JA Fraser, J Heitman - Molecular biology of the cell, 2004 - Am Soc Cell Biol
… further analyzed the roles of Ste20 and Pak1 during mating in C. neoformans. We find that
both Ste20 and Pak1 mediate cell polarity during mating. However, the roles of Ste20 and …

Cell Wall Integrity Pathway Involved in Morphogenesis, Virulence and Antifungal Susceptibility in Cryptococcus neoformans

HC de Oliveira, SA Rossi, I García-Barbazán… - Journal of Fungi, 2021 - mdpi.com
… in the pathogenic fungi, such as Cryptococcus neoformans. This yeast is of particular interest
… In this review, we summarize the components of the CWI pathway in C. neoformans as well …

Conserved Elements of the RAM Signaling Pathway Establish Cell Polarity in the Basidiomycete Cryptococcus neoformans in a Divergent Fashion from Other Fungi

FJ Walton, J Heitman, A Idnurm - Molecular biology of the cell, 2006 - Am Soc Cell Biol
… Here we describe a pathway regulating cell polarization and separation in the human
pathogenic fungus Cryptococcus neoformans. An insertional mutagenesis screen identified roles …

Cell polarity in filamentous fungi: shaping the mold

SD Harris - International review of cytology, 2006 - Elsevier
… of cell polarity, ranging from the complete loss of polarity resulting … polarity axes that enable
the formation of several polarized … nidulans, Ustilago maydis, Cryptococcus neoformans, and …

A Ras1‐Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans

CB Nichols, ZH Perfect, JA Alspaugh - Molecular microbiology, 2007 - Wiley Online Library
neoformans. … , cryptococcal cells undergo a transient loss of cell polarity. One of the roles
of the Ras1 signalling cascade is to re-establish cytoskeletal polarity to allow proper yeast cell

A Putative P-Type ATPase, Apt1, Is Involved in Stress Tolerance and Virulence in Cryptococcus neoformans

G Hu, JW Kronstad - Eukaryotic cell, 2010 - Am Soc Microbiol
… , to the cell surface is a critical aspect of the pathogenicity of Cryptococcus neoformans. A
view of … fusion events for trafficking and in establishing cell polarity. Deletion of the APT1 gene …

Role of Phospholipases in Fungal Fitness, Pathogenicity, and Drug Development – Lessons from Cryptococcus Neoformans

JT Djordjevic - Frontiers in microbiology, 2010 - frontiersin.org
C (PI-C/Plc), in fungal pathogenesis and in particular, what has been learnt about their
function from studies performed in the model pathogenic yeast, Cryptococcus neoformans. These …

Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans

KT Lee, YS So, DH Yang, KW Jung, J Choi… - Nature …, 2016 - nature.com
Cryptococcus neoformans is the leading cause of death by … cell cycle, nutrient metabolism,
stress response and adaptation, … and Kic1 control the cellular polarity and morphology of C. …

Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans

MS Waugh, CB Nichols, CM DeCesare… - …, 2002 - microbiologyresearch.org
… kinases, playing a central role in determining cell polarity and morphogenesis. This protein
appears to … to be a primary regulator of actin cytoskeleton polarity. Similar to our findings in C. …

Fluconazole-induced ploidy change in Cryptococcus neoformans results from the uncoupling of cell growth and nuclear division

S Altamirano, D Fang, C Simmons, S Sridhar, P Wu… - Msphere, 2017 - Am Soc Microbiol
… leaving fungal cells capable of developing drug resistance. The human pathogen Cryptococcus
neoformans … Here we found that FLC treatment leads to an increase in DNA content in C. …