… Cryptococcus neoformans was the most common species isolated in all the studies.
While 26 (89.7%) of the studies were conducted on isolates from incident episodes of …

… Resistance to this antifungal agent has been reported. This study investigated the
patterns of mutation to fluconazole resistance inC. neoformans in vitro. The MIC of …

… is involved in fluconazole resistance of C. neoformans. Our findings therefore reveal that an
active drug efflux mechanism can be involved in the development of azole resistance in this …

… reported in Cryptococcus neoformans strains isolated from an azole therapy failure case of
cryptococcosis in an … In 1999, we reported the occurrence of azole resistance in strains of C. …

… involved in fluconazole resistance in Cryptococcus is limited. Here we report the identification
of an important genetic determinant of fluconazole resistance in C. neoformans that …

… neoformans exists in a significant proportion of clinical isolates and that fluconazole resistance
can … On the other hand, this study confirmed that fluconazole resistance can be developed …

… The effect of temperature on the expression of fluconazole resistance was more profound
for resistant clone B-4548 R derived from the isolate from patient B. Only 9% of the cells of B-…

… neoformans strains in mice and resistance to xenobiotics unrelated to … were more virulent
in mice and more resistant to xenobiotics that are unrelated to fluconazole, as reported for C. …

… neoformans in the environment, the increasing use of triazole fungicides by farmers in
Uganda could be a factor in the increased fluconazole resistance observed in our studies. …

… previously treated with fluconazole [5–9]. Herein, we describe a case of meningitis due to
fluconazole-resistant C. neoformans in an immunocompetent patient without prior exposure to …