… There are a number of DNA extraction options that can be used for ctDNA analysis from
plasma or serum (S3 Table). We chose to compare three methods, all specifically designed for …

… of ctDNA detection in the clinic, here we present a technique which enriches rare mutations
for sequencing, Enrich Rare Mutation … , however the application of ctDNA analyses is still not …

… inhibitors administration on ctDNA-based mutation detection. ctDNA analysis has also been
… the tumor by the so-called blood tumor mutational burden (bTMB). bTMB has recently been …

… work showed that ctDNA analysis is characterized … mutation detected both in liquid biopsy
and in tumor tissue), false positives (T790M mutation detected in liquid biopsy but not detected …

… This is one emerging reason for false-positive results in ctDNA analysis, which is difficult to
… In conclusion, our ctDNA panel and methodology detected ctDNA in the plasma of 13.2% of …

… (17), making targeted mutation approaches to ctDNA analysis more complex compared with
… explanations for the relatively low rate of ctDNA mutation detection in this study. First, HCC …

… ctDNA mutation detection workflow We introduce a method, cmDetect (ctDNA mutation
detection), for the systematic identification of ctDNA mutations by leveraging information from the …

… More research is required to enhance the sensitivity and specificity of mutation detection
in ctDNA. We note that the 1% allele fraction cutoff we used in the ctDNA analysis is for …

… ctDNA analysis methods as well as biological and technical challenges, which need to be
resolved for the integration of ctDNA analysis … more sensitive at mutation detection. Prominent …

… Of the 90 patients submitted for ctDNA analysis as part of clinical care, 68 had provided …
report utilizing the same ctDNA assay of an EGFR T790M mutation detected at progression when …