… and Asp240 than the restricted-spectrum β-lactamase of Bacillus licheniformis, the enzyme
… termini of the omega loop in restricted-spectrum β-lactamases (46). These structural features …

… of the broadspectrum TEM- and SHV-type b-lactamases, which were already widespread
as acquired b-lactamases in the clinical setting when expanded-spectrum cephalosporins …

… extended-spectrum β-lactamase production with a phenotype implying a CTX-M-type β-lactamase…
We examined 291 CTX-M-producing isolates from the UK and investigated the genetic …

Sir, CTX-M extended-spectrum b-lactamases (ESBLs) are increasingly prevalent worldwide
among Escherichia coli and Klebsiella spp., including in the UK, where over half of all …

… CTX-M enzymes, the plasmid-mediated cefotaximases, constitute a rapidly growing family
of extended-spectrum β-lactamases (ESBLs) with significant clinical impact. CTX-Ms are …

… In the last 10 years, extended-spectrum β-lactamase-… because of the current CTX-M enzyme
pandemic. However, most … the issue; and (iii) CTX-M enzymes, especially CTX-M-15, are the …

… extended-spectrum β-lactamase (ESBL) production among Enterobacteriaceae, carried out
in 2003, showed that CTX-M-… molecular epidemiology of the CTX-M-producing isolates from …

… CTX-M-type enzymes are a group of molecular class A extended-spectrum β-lactamases
(ESBLs) that exhibit an overall preference for cefotaxime (CTX; hence the CTX-M name) and …

… β-lactam antibiotics is the production of β-lactamases. Some groups of these enzymes, such
as the group of the extended-spectrum β-lactamases (… hydrolyze oximino-β-lactams such as …

… The plasmid-located bla CTX-M genes were associated with either ISEcp1 or ISCR1 … of
CTX-M-type β-lactamases in Switzerland. Plasmid-mediated extended-spectrum β-lactamases (…