Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts

MV Panchenko, HW Farber… - American Journal of …, 2000 - journals.physiology.org
… We assessed the expression of HO-1 mRNA in normal fibroblasts cultured under hypoxic …
Effect of hypoxia on heme oxygenase-1 (HO-1) mRNA expression by fibroblasts. Fibroblasts

Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts

I Petrache, LE Otterbein, J Alam… - … of Physiology-Lung …, 2000 - journals.physiology.org
Heme oxygenases (HOs) are ubiquitous enzymes that catalyze the initial and rate-limiting
steps in the oxidative degradation of heme to bilirubin; using NADPH and molecular oxygen, …

Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.

GF Vile, S Basu-Modak, C Waltner… - Proceedings of the …, 1994 - National Acad Sciences
… Expression of the heme oxygenase 1 gene is enhanced by … induction of the heme oxygenase
enzyme [heme, hydrogen-… by UVA irradiation of cultured human skin fibroblasts leads to an …

Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells

LA Applegate, P Luscher, RM Tyrrell - Cancer research, 1991 - AACR
… Keyse, SM, Applegate, LA, Tromvoukis, Y., and Tyrrell, RM Oxidant stress leads to
transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts. Mol. Cell. …

Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts

SM Keyse, T Lee Ann Applegate… - … and cellular biology, 1990 - Taylor & Francis
… We measured the half-life of heme oxygenase mRNA in cells exposed to either … of heme
oxygenase mRNA before addition of the transcriptional inhibitor dactinomycin. Heme oxygenase

Two genes contribute to different extents to the heme oxygenase enzyme activity measured in cultured human skin fibroblasts and keratinocytes: implications for …

LA Applegate, A Noël, G Vile, E Frenk… - Photochemistry and …, 1995 - Wiley Online Library
Activation of expression of the heme oxygenase (HO) gene appears to be involved in a cellular
defense system in mammalian cells. We now demonstrate that while HO‐1 mRNA levels …

[HTML][HTML] Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts

PA Dennery, KJ Sridhar, CS Lee, HE Wong… - Journal of Biological …, 1997 - ASBMB
… of heme oxygenase (HO)-1 was evaluated in the oxygen-resistant hamster fibroblast cell line…
hyperoxia, especially in a cell culture model where no exogenous heme has been provided. …

Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin

GF Vile, RM Tyrrell - Journal of Biological Chemistry, 1993 - Elsevier
… , fibroblasts (3,6). We now show that the UVA-dependent increase in heme oxygenase activity
of FEK4 fibroblasts is … pathway we now report to occur in cultured human skin fibroblasts. …

Redox regulation and oxidant activation of heme oxygenase-1

R Tyrrell - Free radical research, 1999 - Taylor & Francis
… The role of heme oxygenase in protection of skin fibroblasts … 1, CL100 phosphatase and
heme oxygenase 1 (HO-1), the … by UVA irradiation of cultured fibroblasts. These proteins are …

Induction of the heme oxygenase gene in human skin fibroblasts by hydrogen peroxide and UVA (365 nm) radiation: evidence for the involvement of the hydroxyl …

SM Keyse, RM Tyrrell - Carcinogenesis, 1990 - academic.oup.com
Induction off the heme oxygenase gene in hydrogen peroxide and UVA (365 mm)
involvement off the hydroxyll radical skin ffibirobl Page 1 CarcinogenesU vol.11 no.5 pp.787-791, …