Evidence of melatonin synthesis in the cumulus oocyte complexes and its role in enhancing oocyte maturation in vitro in cattle

M El‐Raey, M Geshi, T Somfai… - Molecular …, 2011 - Wiley Online Library
… cells in melatonin biosynthesis (Itoh et al., 1999). Moreover, our results suggest that both
oocyte and cumulus cells might play roles together in melatonin biosynthesis by unknown …

Profile of melatonin and its receptors and synthesizing enzymes in cumulusoocyte complexes of the developing sheep antral follicle—a potential estradiol-mediated …

L Xiao, J Hu, L Song, Y Zhang, W Dong, Y Jiang… - Reproductive Biology …, 2019 - Springer
… pattern of melatonin synthesis enzymes AANAT and HIOMT and melatonin receptors MT1
and MT2 in sheep cumulusoocyte complexes (COCs) as well as the change of melatonin

Melatonin improves developmental competence of oocyte-granulosa cell complexes from porcine preantral follicles

Z Cao, D Gao, X Tong, T Xu, D Zhang, Y Wang, Y Liu… - Theriogenology, 2019 - Elsevier
complexes (OGCs) isolated from preantral follicles remains unclear. Cumulus-oocyte complexes
… (N-acetyl-5-methoxytryptamine) is a natural hormone synthesized in the pineal gland …

Daily differential expression of melatonin‐related genes and clock genes in rat cumulusoocyte complex: changes after pinealectomy

LA Coelho, R Peres, FG Amaral… - Journal of pineal …, 2015 - Wiley Online Library
… in cumulus cells and Asmt in COC from immature and mature ovaries indicates the possibility
that both oocyte and cumulus cells synthesize melatonin. In fact, it has been suggested that …

Melatonin Regulates Lipid Metabolism in Porcine CumulusOocyte Complexes via the Melatonin Receptor 2

JX Jin, JT Sun, CQ Jiang, HD Cui, Y Bian, S Lee… - Antioxidants, 2022 - mdpi.com
… (TGs) in cumulus cells. Furthermore, CD36 was a critical FA transporter that transported
available FAs from cumulus cells to oocytes and promoted de novo TG synthesis in the latter. In …

Melatonin influences the sonic hedgehog signaling pathway in porcine cumulus oocyte complexes

S Lee, JX Jin, A Taweechaipaisankul… - Journal of pineal …, 2017 - Wiley Online Library
Melatonin, which is synthesized in the … that melatonin affects in vitro maturation (IVM) of
oocytes and embryonic development in many species. However, beneficial effects of melatonin

Melatonin enhances the in vitro maturation and developmental potential of bovine oocytes denuded of the cumulus oophorus

XM Zhao, JT Min, WH Du, HS Hao, Y Liu, T Qin… - Zygote, 2015 - cambridge.org
… potential of bovine oocytes denuded of the cumulus oophorus (… 10−9 M melatonin (DOs +
MT), cumulusoocyte complexes (… synthesis during in vitro maturation of bovine oocytes: role of …

[HTML][HTML] Melatonin modulates lipid metabolism in porcine cumulusoocyte complex via its receptors

T Zhu, S Guan, D Lv, M Zhao, L Yan, L Shi… - Frontiers in cell and …, 2021 - frontiersin.org
… research demonstrates that melatonin modulates lipid metabolism in maturing oocytes
through its receptors in cumulus cells and benefits the developmental competence of oocytes. …

Melatonin-mediated development of ovine cumulus cells, perhaps by regulation of DNA methylation

Y Fang, S Deng, J Zhang, H Liu, Y Li, X Zhang, Y Liu - Molecules, 2018 - mdpi.com
Cumulus cells from germinal vesicle stage cumulus oocyte complexes (COCs) were … were
fertilized with the same ram fresh sperm in synthetic oviduct fluid medium containing 20% (v/v) …

[HTML][HTML] Melatonin improves the quality of maternally aged oocytes by maintaining intercellular communication and antioxidant metabolite supply

H Zhang, C Li, D Wen, R Li, S Lu, R Xu, Y Tang, Y Sun… - Redox Biology, 2022 - Elsevier
… -cultured cumulus-oocyte complex (COCs). Furthermore, we infused melatonin and CBX …
The melatonin biosynthesis is mediated by the mitochondria to resist free radicals [[22], [23], …