… A small molecule CXCR3 antagonist NIBR2130 in a virus-induced mouse model for T1D
was evaluated. It was found that the overall frequency of T1D was not reduced in mice …

… with type 1 diabetes [13], we hypothesized that aCD3 treatment may spare CXCR3 autoreactive
T … their CXCR3 expression, and (ii) to assess whether the combination of aCD3 with the …

… cells in type 1 diabetes (T1D). Blockade of CXCL10 or genetic deletion of its receptor CXCR3
… to CXCL10 or CXCR3 we evaluated the small molecule CXCR3 antagonist NIBR2130 in a …

… with or implicated in the pathogenesis of type 1 diabetes (T1D), but the identification of a …
receiving CXCR1/2 inhibitor from 12 weeks of age developed diabetes during the follow-up (…

… Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes
in a virus-induced mouse model. Clin Exp Immunol 2011;165:318–328 [PMC free article] […

… be implicated in the pathogenesis of type 1 diabetes (T1D), the … For example, NOD mice
deficient for CXCR3 (CXCL19/… /2 inhibitor alone was able to prevent diabetes progression [46••]…

… T1D frequency and decreased recruitment of CXCR3-positive T cells to the … CXCR3-deficient
RIP-LCMV mice (24). However, a recent follow-up study using aCXCL10-treated or CXCR3-…

… Type 1 diabetes mellitus (T1DM) results from immune cell-mediated … activate CXCR3 are
elevated in non-obese diabetic (NOD) mice, consistent with clinical findings in human diabetes. …

… The significant role of CXCR3 in the immunopathogenesis of type 1 diabetes was directly …
As β cells secrete CXCL10 and CXCL9 during insulitis, the design of CXCR3 antagonists may …

… type 1 diabetes mellitus (T1DM) has been increasing. The role of CXCL10 and its receptor,
CXCR3, … We thus used an antagonist of CXCR3, NBI-74330, to block the specific binding, for …