Regulation of cyclooxygenase enzymes by nitric oxide
D Salvemini - Cellular and Molecular Life Sciences CMLS, 1997 - Springer
… Nitric oxide (NO), derived from L-arginine (L-Arg) by the enzyme nitric oxide synthase (NOS)
is involved in the regulation of several important physiological and pathophysiological …
is involved in the regulation of several important physiological and pathophysiological …
Nitric oxide activates cyclooxygenase enzymes.
D Salvemini, TP Misko, JL Masferrer… - Proceedings of the …, 1993 - National Acad Sciences
… of nitric oxide (NO) on the activity of the constitutive and induced forms of cyclooxygenase
(… The data suggest that NOdirectly interacts with COX to cause an increase in the enzymatic …
(… The data suggest that NOdirectly interacts with COX to cause an increase in the enzymatic …
[HTML][HTML] Molecular mechanisms involved in the reciprocal regulation of cyclooxygenase and nitric oxide synthase enzymes
S Cuzzocrea, D Salvemini - Kidney international, 2007 - Elsevier
… Nitric oxide (NO) is generated via the oxidation of the terminal guanidino nitrogen atom of
L-arginine by nitric oxide synthase (NOS). Three major isoforms of NOS have been identified. …
L-arginine by nitric oxide synthase (NOS). Three major isoforms of NOS have been identified. …
Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.
JR Vane, JA Mitchell, I Appleton… - Proceedings of the …, 1994 - National Acad Sciences
… Thus, there may be differential regulation ofthese enzymes, perhaps due to the … by
cyclooxygenase (COX) to prostaglandin H2 (PGH2). This is further metabolized by other enzymes to …
cyclooxygenase (COX) to prostaglandin H2 (PGH2). This is further metabolized by other enzymes to …
Cyclooxygenase enzymes: regulation and function
FA Fitzpatrick - Current pharmaceutical design, 2004 - ingentaconnect.com
… The cyclooxygenase (COX) enzymes have elaborate roles in human physiology and pathology
[1], … Effects of nitric oxide and nitric oxide-derived species on prostaglandin endoperoxide …
[1], … Effects of nitric oxide and nitric oxide-derived species on prostaglandin endoperoxide …
Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications
D Salvemini, SF Kim, V Mollace - American Journal of …, 2013 - journals.physiology.org
… prostaglandins (pgs) and nitric oxide (NO) are prominent local … complexes [cyclooxygenase
(COX) for PGs and nitric oxide synthase … COX enzymes produce PGH 2 by two-step chemical …
(COX) for PGs and nitric oxide synthase … COX enzymes produce PGH 2 by two-step chemical …
[2] Interactions of nitric oxide with cyclooxygenase: In vitro, ex vivo, and in vivo studies
D Salvemini, JL Masferrer - Methods in enzymology, 1996 - Elsevier
… Nitric oxide (NO), derived from L-arginine (L-Arg) by the enzyme nitric oxide synthase (NOS),
is … cyclase, formation of peroxynitrite, apoptosis, and regulation of cyclooxygenase (COX). …
is … cyclase, formation of peroxynitrite, apoptosis, and regulation of cyclooxygenase (COX). …
Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin
J Kanner, S Harel, R Granit - Lipids, 1992 - Wiley Online Library
… these enzymes. The aim of this study was to demonstrate that nitric oxide acts as an inhibitor
of lipid oxidation by lipoxygenas~ cyclooxygenase and hemeproteins, such as hemoglobin. …
of lipid oxidation by lipoxygenas~ cyclooxygenase and hemeproteins, such as hemoglobin. …
Nitric oxide activates the cyclooxygenase pathway in inflammation
D Salvemini, K Seibert, JL Masferrer… - American Journal of …, 1995 - journals.lww.com
… enzymes has been associated with the pathological roles of these mediators. We have
recently reported that inhibition of nitric oxide production by nitric oxide … the cyclooxygenase …
recently reported that inhibition of nitric oxide production by nitric oxide … the cyclooxygenase …
Cyclooxygenase-2 and nitric oxide
M Hermann - Journal of cardiovascular pharmacology, 2006 - journals.lww.com
… Nitric oxide (NO) is a simple but pluripotent molecule that is mainly released from vascular
endothelial cells where it is formed intracellularly by nitric oxide … , a cyclooxygenase-derived …
endothelial cells where it is formed intracellularly by nitric oxide … , a cyclooxygenase-derived …
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