… the effect of the cyclooxygenase inhibitors nimesulide and diclofenac was probably
mediated through the activation of the NO-cGMP pathway and inhibition of cyclic GMP degradation. …

… The modulation of cellular COX-2 levels, through manifold mechanisms involving its
expression and degradation, makes this biosynthetic pathway suitable to respond to the …

… the preferential counteraction by selective COX-2 inhibitors of CSA hypertension could be
… if the lack of effect of indomethacin on CSA hypertension is a drug or class effect. This was …

… anti‐inflammatory and antiproliferative effects independent of cyclooxy‐genase activity and
prostaglandin synthesis inhibition. These effects are mediated through inhibition of certain …

… of the synthesis of cyclooxygenase-derived prostaglandins … The introduction of the selective
COX-2 inhibitors raised hope … importance of COX-2 derived PGs in the modulation of renal …

… To examine the immune modulating effects of cyclooxygenase type 2 (COX-2) inhibitors (COX-2i)
in HIV-infected patients on combination antiretroviral treatment (CART). …

… , we examined the effect of the nonselective cyclooxygenase inhibitors indomethacin and …
effect of cyclooxygenase inhibitors. However, neither cyclooxygenase inhibitor had an effect …

… -effects of NSAIDs are due to the inhibition of COX-1 (constitutive isoform), whereas the
beneficial effects are related to the inhibition of COX-2 (… effects and showed cytokine-modulating …

… In a study examining the immunologic effects of parecoxib (a selective COX-2 inhibitor) in
adults undergoing laparoscopic cholecystectomy, the balance between T helper 1 cells, T …

… their main therapeutic effects as being COX-2-dependent and their … a new class of selective
COX-2 inhibitors, the coxibs. This review will … Moreover, COX-2 may play a role in modulating …