… mediated cerivastatin transport by cyclosporin, rather than inhibition of its cytochrome P450
(CYP)… enzymes and transporters may occur to a lesser extent in individuals who carry these. …

… aware of DDIs caused by the inhibition of these transporters. … acts as an inducer of metabolic
enzymes and transporters.Lau et al. … is not metabolized by cytochrome P450. Thus, these …

… Of the 11 human OATP transporters, OATP1B1, OATP1B3 and OATP2B1 are expressed on
the … of other drug transporters and often subject to metabolism by CYP enzymes (Smith et al., …

… cytochrome P450 (CYP) enzymes and organic anion transporting polypeptide 1B1 (OATP1B1
transporter) … of meglitinides involving CYP enzymes and OATP1B1 transporter. To prevent …

… of hepatic uptake transporters like OATP1B1 and OATP1B3 (… of metabolic enzymes and
uptake transporters on the hepatic … these drugs should inhibit these CYP enzymes at that time. …

… transporters (OATP1B1, OATP1B3, and NTCP), and OAT3 on the disposition of statins, alone
or in concert with CYP… against the transporters and drug-metabolizing enzymes deemed …

… in the pharmacogenomics of OATP1B1 have revealed that OATP transporters can play …
-metabolizing enzymes, rifampicin has been shown to increase the expression of OATP1B1 in …

… not substrates of CYP enzymes and hence the concomitant use of CYP inhibitors or inducers
… strates of OATP1B1 transporter, and the co-prescription of inhibitors of OATP1B1 elevates …

… from transporter interactions. In contrast, SKF-525A another nonselective CYP inhibitor not
… but also inhibited uptake transporter activities mediated by OATP1B1, OATP1B3 and OCT1. …

… mediated by CYP enzymes, although other enzymes, such as … are further detoxified by
enzymes via conjugation reactions, … to have an effect on OATP1B1 transporter function. Niemi et al…