[HTML][HTML] Prediction of CYP2D6 phenotype from genotype across world populations

A Gaedigk, K Sangkuhl, M Whirl-Carrillo, T Klein… - Genetics in …, 2017 - nature.com
… The accuracy of actionable CYP2D6 phenotypes prediction by genetic analysis could be …
In summary, we present CYP2D6 phenotype predictions based on the most comprehensive, …

Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations

A LLerena, MEG Naranjo… - Expert opinion on …, 2014 - Taylor & Francis
… In conclusion, relative to the distribution of the world’s population, CYP2D6 research on …
variability of CYP2D6 allelic frequencies across geographic and ethnic groups: CYP2D6*10 …

[HTML][HTML] Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19

AB Koopmans, MH Braakman, DJ Vinkers… - Translational …, 2021 - nature.com
… In order to predict CYP2D6 and CYP2C19 phenotype frequencies from genotype data, we
… Our results suggest that more than half of the world population has a non-normal CYP2D6

CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure

J Sistonen, A Sajantila, O Lao, J Corander… - Pharmacogenetics …, 2007 - journals.lww.com
… in CYP2D6 metabolism among regions of the world we used a conventional classification of
phenotypes … many different groups of populations were supported by CYP2D6 data from this …

[HTML][HTML] Distribution of CYP2D6 Alleles and Phenotypes in the Brazilian Population

DC Friedrich, JP Genro, VA Sortica, G Suarez-Kurtz… - PloS one, 2014 - journals.plos.org
… clinics and given the paucity of CYP2D6 data in the Brazilian population, the purpose of this
… ancestry in CYP2D6 alleles, genotype and predicted phenotype distributions in Brazilians. …

[HTML][HTML] CYP2D6 overview: allele and phenotype frequencies

M Kane - Medical Genetics Summaries [Internet], 2021 - ncbi.nlm.nih.gov
… This review summarizes the phenotype frequencies among global populations from over …
poor, intermediate, or ultrarapid) phenotype frequencies for CYP2D6 and CYP2C19 to facilitate …

Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization

J Kevin Hicks, JJ Swen, A Gaedigk - Current drug metabolism, 2014 - ingentaconnect.com
… metabolic ratio of a probe drug to its metabolite, these original studies revealed a bimodal
population distribution of CYP2D6 activity. The majority of individuals with low or absent …

[HTML][HTML] Frequencies of CYP2D6 genetic polymorphisms in Arab populations

M Alali, W Ismail Al-khalil, S Rijjal, L Al-Salhi, M Saifo… - Human Genomics, 2022 - Springer
… estimated the frequency of different CYP2D6 phenotypes where applicable [7]. Furthermore,
… , determining the frequencies of CYP2D6 alleles across world populations as well as …

CYP2D6 extensive, intermediate, and poor phenotypes and genotypes in a Polish population

P Niewinski, K Orzechowska-Juzwenko… - European journal of …, 2002 - Springer
… of the CYP2D6 genotypes and phenotypes in a Polish population … The CYP2D6 phenotype
was analyzed in 300 individuals … of CYP2D6 phenotypes and genotypes in white populations. …

CYP2D6 genotype and phenotype determination in a Mexican Mestizo population

M López, J Guerrero, H Jung–Cook… - European journal of …, 2005 - Springer
… first analysis of CYP2D6 phenotype and genotype in a Mexican Mestizo population to date.
frequency of poor metabolizers (10%) in the Mexican Mestizo population studied was very …