[HTML][HTML] Prediction of CYP2D6 phenotype from genotype across world populations
A Gaedigk, K Sangkuhl, M Whirl-Carrillo, T Klein… - Genetics in …, 2017 - nature.com
… The accuracy of actionable CYP2D6 phenotypes prediction by genetic analysis could be …
In summary, we present CYP2D6 phenotype predictions based on the most comprehensive, …
In summary, we present CYP2D6 phenotype predictions based on the most comprehensive, …
Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations
A LLerena, MEG Naranjo… - Expert opinion on …, 2014 - Taylor & Francis
… In conclusion, relative to the distribution of the world’s population, CYP2D6 research on …
variability of CYP2D6 allelic frequencies across geographic and ethnic groups: CYP2D6*10 …
variability of CYP2D6 allelic frequencies across geographic and ethnic groups: CYP2D6*10 …
[HTML][HTML] Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19
AB Koopmans, MH Braakman, DJ Vinkers… - Translational …, 2021 - nature.com
… In order to predict CYP2D6 and CYP2C19 phenotype frequencies from genotype data, we
… Our results suggest that more than half of the world population has a non-normal CYP2D6 …
… Our results suggest that more than half of the world population has a non-normal CYP2D6 …
CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure
J Sistonen, A Sajantila, O Lao, J Corander… - Pharmacogenetics …, 2007 - journals.lww.com
… in CYP2D6 metabolism among regions of the world we used a conventional classification of
phenotypes … many different groups of populations were supported by CYP2D6 data from this …
phenotypes … many different groups of populations were supported by CYP2D6 data from this …
[HTML][HTML] Distribution of CYP2D6 Alleles and Phenotypes in the Brazilian Population
… clinics and given the paucity of CYP2D6 data in the Brazilian population, the purpose of this
… ancestry in CYP2D6 alleles, genotype and predicted phenotype distributions in Brazilians. …
… ancestry in CYP2D6 alleles, genotype and predicted phenotype distributions in Brazilians. …
[HTML][HTML] CYP2D6 overview: allele and phenotype frequencies
M Kane - Medical Genetics Summaries [Internet], 2021 - ncbi.nlm.nih.gov
… This review summarizes the phenotype frequencies among global populations from over …
poor, intermediate, or ultrarapid) phenotype frequencies for CYP2D6 and CYP2C19 to facilitate …
poor, intermediate, or ultrarapid) phenotype frequencies for CYP2D6 and CYP2C19 to facilitate …
Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization
J Kevin Hicks, JJ Swen, A Gaedigk - Current drug metabolism, 2014 - ingentaconnect.com
… metabolic ratio of a probe drug to its metabolite, these original studies revealed a bimodal
population distribution of CYP2D6 activity. The majority of individuals with low or absent …
population distribution of CYP2D6 activity. The majority of individuals with low or absent …
[HTML][HTML] Frequencies of CYP2D6 genetic polymorphisms in Arab populations
… estimated the frequency of different CYP2D6 phenotypes where applicable [7]. Furthermore,
… , determining the frequencies of CYP2D6 alleles across world populations as well as …
… , determining the frequencies of CYP2D6 alleles across world populations as well as …
CYP2D6 extensive, intermediate, and poor phenotypes and genotypes in a Polish population
P Niewinski, K Orzechowska-Juzwenko… - European journal of …, 2002 - Springer
… of the CYP2D6 genotypes and phenotypes in a Polish population … The CYP2D6 phenotype
was analyzed in 300 individuals … of CYP2D6 phenotypes and genotypes in white populations. …
was analyzed in 300 individuals … of CYP2D6 phenotypes and genotypes in white populations. …
CYP2D6 genotype and phenotype determination in a Mexican Mestizo population
M López, J Guerrero, H Jung–Cook… - European journal of …, 2005 - Springer
… first analysis of CYP2D6 phenotype and genotype in a Mexican Mestizo population to date.
frequency of poor metabolizers (10%) in the Mexican Mestizo population studied was very …
frequency of poor metabolizers (10%) in the Mexican Mestizo population studied was very …
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