… of allelic cytochrome P450 (P450 or CYP) variants is essential for efficient and safe drug
treatment and for successful drug development. In the current overview, we emphasize some …

… among cytochromes P450, provide tools for a personalized medicine treatment, which can
make drug … Much of the pioneering work linking drug metabolizing phenotype to genetic …

… The present review is an update on the CYP hemeproteins with emphasis … cerned with the
detoxication of drugs and xenobiotics. While phase I cytochrome P450 enzymes catalyze the …

… systems with particular emphasis on their role as drug targets, their involvement in drug
biosynthesis and potential strategies for developing new derivatives of drugs based on CYP …

… : drug interactions and interindividual variability in drug metabolism. … of cytochrome
P450-mediated drug metabolism have been … emphasis on functional genomic approaches to P450 …

… drug metabolism and toxicity became appreciated, and the roles of cytochrome P450 (P450) …
Today we understand much about the metabolism of drugs and many aspects of safety …

… The estimated fraction of responsibility of the respective enzyme for drug metabolism in
phase 1 reactions as a percentage of drugs metabolized by all cytochrome P450 enzymes. Data …

… the large fraction of drugs metabolized by P450 2D6 (Evans … I refer readers to the new edition
of Cytochrome P450, edited … I have emphasized some basic research problems, but much …

… drug metabolism catalyzed by cytochrome P450 (CYP) enzymes. Phase I reactions introduce
reactive or polar groups (-OH, -COOH, -NH 2 , -SH, etc.) into drugs, … It is worth emphasizing …

… of the cytochrome P450 (CYP) genes affects individual drug … , antipsychotics, antiulcer
drugs, anti-HIV drugs, anticoagulants, … with emphasis on novel aspects of clinical importance. …