Cytochrome P450 expression and regulation in the brain
W Kuban, WA Daniel - Drug Metabolism Reviews, 2021 - Taylor & Francis
… The regulation of brain cytochrome P450 enzymes (CYPs) is … differentiated expression and
susceptibility to the regulation of … brain, and discuss brain-specific regulation of CYP genes. In …
susceptibility to the regulation of … brain, and discuss brain-specific regulation of CYP genes. In …
Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation
EL LeCluyse - European journal of pharmaceutical sciences, 2001 - Elsevier
… for optimal phenotypic gene expression and response to drugs … of cytochrome P450 (CYP450)
enzyme regulation have been … expression of the individual isoforms of the major CYP450 …
enzyme regulation have been … expression of the individual isoforms of the major CYP450 …
Cytochrome P450 3A and their regulation
O Burk, L Wojnowski - Naunyn-Schmiedeberg's archives of pharmacology, 2004 - Springer
… Here we summarise the current status of our understanding of the genetics and regulation
of the expression of CYP3A, including the recently described markers of the CYP3A5 and …
of the expression of CYP3A, including the recently described markers of the CYP3A5 and …
[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
UM Zanger, M Schwab - Pharmacology & therapeutics, 2013 - Elsevier
… , induction by xenobiotics, regulation by cytokines, hormones … variants in regulatory genes
or in NADPH:cytochrome P450 … , interindividual variability and regulation of expression, and …
or in NADPH:cytochrome P450 … , interindividual variability and regulation of expression, and …
Regulation of the cytochrome P450 2A genes
T Su, X Ding - Toxicology and applied pharmacology, 2004 - Elsevier
… we study the regulation of the mouse Cyp2a genes to ensure that we consider the specificity
of detection of the individual Cyp2a genes and the variability of their expression in different …
of detection of the individual Cyp2a genes and the variability of their expression in different …
Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung
J Hukkanen, O Pelkonen, J Hakkola… - Critical reviews in …, 2002 - Taylor & Francis
… are mostly catalyzed by cytochrome P450 (CYP) … the expression of individual CYP forms
in human pulmonary tissue and gives a view on the significance of the pulmonary expression of …
in human pulmonary tissue and gives a view on the significance of the pulmonary expression of …
Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes
EL LeCluyse, A Madan, G Hamilton… - … of biochemical and …, 2000 - Wiley Online Library
… P450 enzyme modulation in humans. The aim of this study was to test in vitro conditions for
evaluating drugs as cytochrome P450 in… in the induction response for various P450 enzymes. …
evaluating drugs as cytochrome P450 in… in the induction response for various P450 enzymes. …
Mechanisms of cytochrome P450 regulation by inflammatory mediators
ET Morgan, T Li-Masters, PY Cheng - Toxicology, 2002 - Elsevier
… that confers down-regulation of a linked … P450 expression, but reports from different
laboratories have disagreed on this subject. Recently, we found that LPS suppresses the expression …
laboratories have disagreed on this subject. Recently, we found that LPS suppresses the expression …
Role of NF-κB in the regulation of cytochrome P450 enzymes
BNM Zordoky, AOS El-Kadi - Current drug metabolism, 2009 - ingentaconnect.com
… -κB in CYP regulation. We proposed three mechanisms by which NF-κB can regulate CYP
expression and activity. First, NF-κB can directly regulate the expression of CYP1A1, CYP2B1/…
expression and activity. First, NF-κB can directly regulate the expression of CYP1A1, CYP2B1/…
Regulation of cytochrome P450 expression in Drosophila: Genomic insights
… expression in larval and adult Drosophila tissues. We also compared various insecticides
and xenobiotics for their ability to induce this cytochrome P450 … reports on P450 induction that …
and xenobiotics for their ability to induce this cytochrome P450 … reports on P450 induction that …
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