The levels and activities of cytochrome P450 enzymes are influenced by a variety of factors,
including the diet. In this article, the effects of selected non‐nutritive dietary chemicals, …

… other laboratories, which have been focussed on the zonation of cytochrome P450 enzymes
and phase II enzymes and on their possible consquences for zonated toxicity in the liver. …

… Cytochrome P450 (P450) enzymes catalyze a variety of reactions and convert chemicals
to potentially reactive products as well as make compounds less toxic. Most of the P450 …

… The cytochrome P450 (P450) enzymes are the major catalysts involved in the metabolism of
… In the article we consider what fraction of drug toxicity actually involves metabolism, and we …

… plethora of different cytochromes P450, the … cytochrome P450. A short internet search has
revealed a very intense as well as an almost uniform distribution of interest into the cytochrome …

… Cytochromes P450 are oxidizing enzymes; a few families of cytochromes P450 are
implicated in drug metabolism. These enzymatic reactions involve many processes including (i) …

Through their unique oxidative chemistry, cytochrome P450 … mediators, cytochrome P450
reductase and cytochrome b5. … paths of metabolism and the production of toxic metabolites. …

… Cytochromes P450 are responsible for metabolism of most … toxicity, cell death and sometimes
cellular transformation resulting in cancer. To establish the role of these enzymes in toxicity …

… Much has been written about cytochrome P450 (P450, CYP). In this review I will deal with
one aspect of P450, drug toxicity, and the history of how this developed. Metabolism will be …

… Cytochrome P450-dependent metabolism of most xenobiotics leads to their detoxication …
compounds are also activated to intermediates that are toxic and/or carcinogenic [eg Refs. 46 …