… cytochrome P450 (P450, CYP). In this review I will deal with one aspect of P450, drug toxicity,
… discussed in the context of causing (or preventing) toxicity, aside from drug efficacy per se. …

… of a particular P450 or that P450 is inhibited by another drug, toxicity may develop, particularly
if drug accumulation occurs upon multiple doses. Drug–drug interactions are recognized …

… plethora of different cytochromes P450, the … cytochrome P450. A short internet search has
revealed a very intense as well as an almost uniform distribution of interest into the cytochrome …

… cytochrome P450 (P450) enzymes are the major catalysts involved in the metabolism of
drugs… , those of most interest with drugs (and with other chemicals for which toxicity is an issue) …

… liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens, and toxic
chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. …

… Cytochromes P450 are responsible for metabolism of most xenobiotics and are required for
… Drug toxicity can be affected by polymorphisms in P450s and drug interactions. Humans …

… of several drugs. Drug metabolism via the cytochrome P450 system has emerged as an
important … in the occurrence of several drug interactions that can result in drug toxicities, reduced …

… Upregulation of CYP3A4 can also exaggerate toxic responses to drugs as with rifampicin …
sion of cytochromes P450 2E1 and 2B in primary cultured rat hepatocytes. Drug Metab Dispos …

… and the toxicity of anticancer drugs [2]. Drug metabolism is known to be catalyzed by a
range of drug-metabolizing enzymes including the cytochromes P450 (CYPs). CYPs are heme-…

… for drug toxicity. Increased knowledge of the mechanisms behind ADRs because of allelic
cytochrome P450 (P450 or … mainly on the influence of genetic polymorphism on drug toxicity. …