… that caspase-8 downstream of TLRs regulates cytokine production from hBMSCs. The induction
of pro-inflammatory cytokines, such as IL-1β, IL-6, … on caspase-8. In contrast, silencing of …

… T cells expressing the non-cleavable caspase-8 D387A mutant are activated upon TCR …
auto-processing of caspase-8 for optimal TLR-induced cytokine expression.78 Caspase-8 also …

… , caspase-8 also appears to be mediating optimal transcription of certain inflammatory cytokines
… overview of the many roles of caspase-8 and exemplify how caspase-8 is involved in the …

… for caspase-8, including its ability to repress necroptosis, regulate cytokine transcription, …
Unexpectedly, in vivo cytokine responses to LPS were blunted in Caspase-8 LysMCre mice, …

… caspase-8 enzymatic activity and scaffolding functions contribute to inflammatory cytokine
gene expression… observation that caspase-8 controls cytokine gene expression via catalytic …

… expression and host defense during in vivo infection is unknown. Here, we show that
caspase-8 activity promotes cell-intrinsic cytokine expression, … that caspase-8 enzymatic activity …

… Thus, the downregulation of cytokine expression and angiogenesis by trabectedin and … of
caspase-8, which highlights a possible therapeutic role of caspase-8 in the modulation of TME. …

… required pro-apoptotic caspase-8 in addition to pro-pyroptotic caspase-11 and gasdermin
D… cytokines sufficient to initiate shock without any contribution from caspase-8 or caspase-11. …

… Thus, when Caspase-8 is blocked, necroptosis can be induced as an … cytokines and
Damage-Associated Molecular Patterns (DAMPs), leading to the onset of inflammation. Caspase 8 …

… among caspases. Despite these substitutions found in c-FLIPL, it has recently been shown
that caspase8-c-… expressed protein that is activated by a number of cytokines, including IL-6. …