The IL-2 cytokine family in cancer immunotherapy

GC Sim, L Radvanyi - Cytokine & growth factor reviews, 2014 - Elsevier
… of these cytokines for cancer immunotherapy are also described. … cytokines, such as the
development of new cytokine mutants and variants for improving cytokine-based immunotherapy

Cytokines in cancer immunotherapy

TA Waldmann - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
cytokines along with antibodies to checkpoint proteins, the use of cytokines with anticancer
vaccines, and cytokines … is to review the cytokines involved in cancer immunotherapy and to …

[HTML][HTML] Cytokines in clinical cancer immunotherapy

P Berraondo, MF Sanmamed, MC Ochoa… - … journal of cancer, 2019 - nature.com
cytokines that potentiate immune responses against cancer, we focus our review on IFN-α,
the IL-2 family, IL… In the case of immunosuppressive cytokines, we describe strategies to block …

[HTML][HTML] IL-12 family cytokines in cancer and immunotherapy

B Mirlekar, Y Pylayeva-Gupta - Cancers, 2021 - mdpi.com
… an effector cytokine and has … cytokine and plays a largely pro-tumorigenic role by inhibiting
effector T cells. In this review, we summarize the recent findings on IL-12 family cytokines in …

[HTML][HTML] Cytokines in cancer immunotherapy

S Lee, K Margolin - Cancers, 2011 - mdpi.com
cancer treatments. The goal of this paper is to review the major cytokines involved in cancer
immunotherapy and … The paper will also describe new cytokines in pre-clinical development, …

[HTML][HTML] The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy

B Boersma, W Jiskoot, P Lowe, C Bourquin - Cytokine & growth factor …, 2021 - Elsevier
… IL-1) family is one of the first described cytokine families and consists of eight cytokines (IL-1β…
The family members are known to play an essential role in inflammation. The importance of …

Next-generation cytokines for cancer immunotherapy

D Xue, E Hsu, YX Fu, H Peng - Antibody therapeutics, 2021 - academic.oup.com
… This review focuses on selected cytokines, including interferon-α… We review next-generation
designs of these cytokines that … new strategies to potentiate cytokine-based immunotherapy. …

[HTML][HTML] Mechanisms and αpplications of ιnterleukins in cancer immunotherapy

D Anestakis, S Petanidis, S Kalyvas, CM Nday… - International journal of …, 2015 - mdpi.com
… the major cytokines-interleukins involved in cancer immunotherapy and project their … cytokines
in pre-clinical development, and potential directions for future investigation using cytokines

Suppressors of cytokine signaling: potential immune checkpoint molecules for cancer immunotherapy

S Chikuma, M Kanamori, S Mise‐Omata… - Cancer …, 2017 - Wiley Online Library
… the third signal: signals from the cytokine receptors (Fig. 1). For … Thus, negative regulators of
the cytokine signaling must be … suppressors of cytokine signaling (SOCS) family proteins and …

Clinical application of cytokines in cancer immunotherapy

Y Qiu, M Su, L Liu, Y Tang, Y Pan… - Drug design, development …, 2021 - Taylor & Francis
… Here, we provide an overview of the various roles of cytokines in the cancer immunity cycle,
… of cytokine-based drugs in cancer therapy. We review 27 cytokines in 2630 cancer clinical …