Novel strategies exploiting interleukin-12 in cancer immunotherapy

A Cirella, C Luri-Rey, CA Di Trani, A Teijeira… - Pharmacology & …, 2022 - Elsevier
cytokine signaling (SOCS) family of phosphatases. From the perspective of immune system
function, this family of cytokines … These cytokines are key for the control of the differentiation …

Immunocytokines: a promising approach to cancer immunotherapy

HN Lode, R Xiang, JC Becker, SD Gillies… - Pharmacology & …, 1998 - Elsevier
… We recently demonstrated the feasibility of such an alternative approach to cancer
immunotherapy that achieves an effective concentration of cytokines in the tumor microenvironment. …

Cancer immunotherapy with cytokine-induced killer cells

JJ Mata-Molanes, M Sureda González… - Targeted …, 2017 - Springer
… In the last decade, cancer immunotherapy has received considerable interest in the scientific
and clinical communities, becoming a promising treatment option for various cancers, in …

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
… provide a timely update on the biology of IL-6 family cytokines and their clinical potential as
therapeutic targets or disease modifiers in autoimmunity, inflammation, infection and cancer. …

Cytokine patterns in patients with cancer: a systematic review

BE Lippitz - The lancet oncology, 2013 - thelancet.com
… to the heterogeneity of cancer theories of common reaction … with cancer, expression and
interplay of the following cytokines … of tumor growth by IFN-gamma in cancer immunotherapy. …

Kinoids: a family of immunogens for active anticytokine immunotherapy applied to autoimmune diseases and cancer

B Bizzini, B Drouet, D Zagury, M Abitbol, A Burny… - …, 2010 - Taylor & Francis
cytokines TNF-α, IL-1-β and IL-6 are critical mediators in the inflammatory process of arthritis,
while the cytokine … A wide range of cytokines are currently used in passive immunotherapy

[HTML][HTML] Cytokines in immunogenic cell death: applications for cancer immunotherapy

A Showalter, A Limaye, JL Oyer, R Igarashi… - Cytokine, 2017 - Elsevier
… from inhibitory to activating cytokines in order to generate a protective anti-cancer response,
… challenge for successful immunotherapy approaches. One way that cancers evade the …

Cytokine-like Molecule CCDC134 Contributes to CD8+ T-cell Effector Functions in Cancer Immunotherapy

J Huang, L Xiao, X Gong, W Shao, Y Yin, Q Liao… - Cancer research, 2014 - AACR
… receptor family. Overall, our results provide evidence that CCDC134 may serve as a member
of the γ c cytokine family and illustrate its … Cancer Res; 74(20); 5734–45. ©2014 AACR. …

Harnessing cytokines and chemokines for cancer therapy

DJ Propper, FR Balkwill - Nature reviews Clinical oncology, 2022 - nature.com
… The advent of more effective immunotherapies and an … to harnessing cytokine networks in
the treatment of cancer, … both cytokine and anti-cytokine approaches to cancer therapy herein. …

Chemokines and chemokine receptors: new targets for cancer immunotherapy

V Mollica Poeta, M Massara, A Capucetti… - Frontiers in …, 2019 - frontiersin.org
… of cancer (1, 2). Chemokines, are a family of small, secreted, and structurally related cytokines
… They are also key mediators of cancer related inflammation being present at tumor site for …