Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
… autoimmune conditions with drugs that target the IL-6 pathway. Here, we discuss the emerging
roles for IL-6 family members in infection, chronic inflammation, autoimmunity and cancer

IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases

X Song, Y Qian - Cellular signalling, 2013 - Elsevier
… , metabolic disorders and cancer. Interleukin (IL)-17 … , we highlight the up-to-date knowledge
of this family cytokines and their impacts on the pathogenesis of inflammatory diseases. …

Function and regulation of IL‐1α in inflammatory diseases and cancer

A Malik, TD Kanneganti - Immunological reviews, 2018 - Wiley Online Library
diseases and cancer. While the regulation and function of IL-1β and other IL-1 cytokines
has … understanding of regulation and function of IL-1α in inflammatory diseases and cancer. …

IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets

N Unver, F McAllister - Cytokine & growth factor reviews, 2018 - Elsevier
IL-6 is a critical cytokine in acute phase response and involved in the pathogenesis of …
inflammatory diseases including cancer. Studies have highlighted that levels of IL-6 and its family

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer

T Putoczki, M Ernst - Journal of leukocyte biology, 2010 - academic.oup.com
… members of this cytokine family. In this review, we focus on IL-11 as a member of the IL-6
family of cytokines that has been implicated recently in linking inflammation to cancer within the …

The interleukin (IL)-1 cytokine family–Balance between agonists and antagonists in inflammatory diseases

J Palomo, D Dietrich, P Martin, G Palmer, C Gabay - Cytokine, 2015 - Elsevier
… of the body to stop the inflammatory response will end in uncontrolled destruction of …
inflammatory diseases, allergies or cancer. The interleukin (IL)-1 family includes a set of cytokines, …

Cytokines in inflammatory disease

S Kany, JT Vollrath, B Relja - International journal of molecular sciences, 2019 - mdpi.com
… abolished the IL-6 levels [44]. … IL-6 can be a predictor of survival in head and neck cancer
[45]. Yet, it often remains unclear if IL-6 is only correlative to cancer or rather essential in cancer

Inflammatory cytokines in the pathogenesis of cardiovascular disease and cancer

MN Amin, SA Siddiqui, M Ibrahim… - SAGE open …, 2020 - journals.sagepub.com
inflammatory cytokines are also well known to induce numerous chronic inflammatory disorders
Recent study has reported that increased release of cytokines, including TNF-α, IL-6 and …

SOCS proteins in immunity, inflammatory diseases, and immune-related cancer

ML Sobah, C Liongue, AC Ward - Frontiers in medicine, 2021 - frontiersin.org
… Signaling by cytokines needs to be tightly controlled in order … inflammatory conditions,
increased susceptibility to infectious … IL-6 family of cytokines that act via STAT3, notably including …

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

SI Grivennikov, M Karin - Annals of the rheumatic diseases, 2011 - ard.bmj.com
… Another inflammation-linked cancer in which inflammatory cytokines have a significant role
… of liver cancer. HCC often develops in association with chronic liver inflammation caused by …