… Rheumatoid arthritis (RA) is an … network of various cytokines and cells that trigger synovial
cell proliferation and cause damage to both cartilage and bone. Involvement of the cytokines …

… Concepts of cytokine networks in RA that contribute to synovial inflammation and autoimmunity
are therefore currently evolving to embrace strategic cytokine inhibition early in disease, …

… Finally, we formed the cytokine network by connecting the cytokines, their transcription
factors, the intermediates that connect them and the neighborhood nodes of the intermediates […

… Fibroblast-like synoviocytes play important roles at several levels in the pathophysiology of
rheumatoid synovitis (22). The cytokine networks in this inflamed tissue greatly influence the …

… The implications of such a new taxonomic approach are broad; for example, placement of
as-yet undescribed or therapeutically tested cytokines or inhibitors in such networks could …

… The proinflammatory cytokine network can serve as a final … and specific cytokines, such
as the widely variable role of IL-6, … events can have some distinctive cytokine characteristics. …

… To update the knowledge accumulated on the contribution of cytokines to rheumatoid
arthritis and related animal models. Publications from the end of 2002 and 2003 period were …

… role of IL-6 in epithelial homeostasis 4 , IL-6 inhibition shows … the adverse effects of IL-6
inhibition in rheumatoid arthritis is … The lack of efficacy of IL-6 inhibition in psoriatic arthritis and …

… cytokines have an inflammatory role in rheumatoid arthritis is unclear. The observation of a
reduction in adjuvant-induced arthritis by … Here, we describe the cytokine network in terms of …

Although a notable amount of CCL20 is detectable in the synovial fluid of human rheumatoid
arthritis (RA), its role in the pathogenesis of RA remains to be determined. IL-1β vigorously …