… potent tumor cell killing with high levels of cytokine release. In … that decouples tumor cell
killing from cytokine release. Toward … in vivo tumor cell killing and low levels of cytokine release. …

… Citation 16,28,46 We have previously reported a macrophage-mediated tumor cell-killing
assay that assesses the total loss of tumor cells over a 24-h period as opposed to the more …

… We compared the cytokine release patterns of CD8+ selected TIL cultures to their bulk (unselected)
analogs. There was significant variability in the cytokine secretion patterns of CD8+ …

… by noncompeting NKCEs still eliciting tumor cell killing at low picomolar concentrations. …
tumor cell lysis than cetuximab and elicited a robust release of proinflammatory cytokines, …

… TNB-585 combines a tumor-targeting anti-PSMA arm together with our low … killing of prostate
tumor cells with minimal cytokine release. TNB-585 mediated killing of PSMA + tumor cells (…

… (71), and cytokine profiles measured in peripheral … cytokine may play a prominent role in
either tumor killing or cancer promotion. Although the original stimuli of inflammatory cytokine …

… cells also resulted in the release of these two cytokines by treated … tumor cell pyroptosis.
However, supernatants from nontransduced tumor-specific CD8 + T cells that killed target tumor …

… We demonstrated that TGF-β1 suppressed TIL killing activity. TIL isolated from regressing …
that IL-6 alone did not significantly increase LAK killing activity, which implies that IL-6 does …

… As the most likely subset of immune cells with tumor-killing activity, NK cell activity was … act
effectively against tumors. Type II ICD inducers shared a similar cytokine release profile with …

… cells after exposure to tumor cells is closely related to their killing activity. Generally, CAR-T
cells with either CD28 or 4-1BB signal domain secret more cytokines than the first generation …