Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19

M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
… )-2, IL-4, IL-6, IL-8, IL-1β, and so forth. Characterized as “cytokine storm” that may have
occurred due to an imbalanced immune system. The cytokine storm is also considered to be one …

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - Expert Opinion on …, 2020 - Taylor & Francis
… The cytokine storm of COVID-19 is an important instigator of severe disease and multi-organ
injury. We describe the immune-modulating therapies which are currently under review in …

The novel immunomodulatory biologic LMWF5A for pharmacological attenuation of the “cytokine storm” in COVID-19 patients: a hypothesis

G Thomas, E Frederick, M Hausburg, L Goldberg… - Patient Safety in …, 2020 - Springer
… potentially critical for cytokine storm development. Interestingly, T-… the potential development
of a cytokine storm as well as the … to bridge our research to modulation of key inflammatory …

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been … Cytokine storms (CSs) are associated
with various pathologies, … cytokine release and cell death pathways; certain cytokines, …

Targeting the “cytokine storm” for therapeutic benefit

RV D'Elia, K Harrison, PC Oyston… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
… tularensis , do trigger life-threatening “cytokine storms” in the host which can result in …
We review some of the current candidates for treatment of cytokine storms which may prove …

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V Kumar - International immunopharmacology, 2020 - Elsevier
… Toll-like receptors (TLRs) are one of the major pattern recognition receptors (PRRs) … ,
which play a crucial role in generating cytokine storm. They recognize microbial-associated …

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

F Coperchini, L Chiovato, L Croce, F Magri… - Cytokine & growth factor …, 2020 - Elsevier
… that the term cytokine storm was first employed in describing the events modulating the onset
of … Cytokine storms characterize a wide spectrum of infectious and non-infectious diseases, …

[HTML][HTML] The cytokine storm of severe influenza and development of immunomodulatory therapy

Q Liu, Y Zhou, Z Yang - Cellular & molecular immunology, 2016 - nature.com
… initiate the cytokine storm and … of cytokine storms in severe influenza, including corticosteroids,
peroxisome proliferator-activated receptor agonists, sphingosine-1-phosphate receptor 1 …

Cytokine storm in COVID-19: Potential therapeutics for immunomodulation

MM Rana - Journal of Research in Clinical Medicine, 2020 - library.2pressrelease.co.in
… These results suggest that JAK inhibitors may be effective in reducing the clinical symptoms
via modulating inflammatory cytokines in the different organs like the lungs, kidneys, and …

Into the eye of the cytokine storm

JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
Cytokine storms are … the cytokine storm in the context of virus infection, and we highlight
how high-throughput genomic methods are revealing the importance of the kinetics of cytokine