… as a type II IFN. Additional IFNs have … IFN-a (2-4, 11). This review focuses on important
clinical models and principles that serve as guidelines for future advances in cytokine therapeutics…

… Research is progressing rapidly in the area of cytokines and their therapeutic targets, the
two major therapeutic modalities being the administration of purified recombinant cytokines …

… Here, we review cytokine therapeutics marketed in the United States and in Europe, aspects
… There are decades between the market introduction of the first and the most recent cytokine …

… therapeutic development of IFNs, particularly IFN-β, as an example of a successful cytokine
therapeutic… as an example of an anti-cytokine therapeutic that has revolutionized treatment of …

… cytokines are involved in a broad range of biological processes and are implicated in various
disease pathologies. The field of cytokine therapeutics … methods to develop cytokine-based …

… Infliximab, a monoclonal antibody against the pro-inflammatory cytokine TNF-alpha has
been successfully applied as a treatment for Crohn's disease. The mechanism of action of this …

… Treatment of these patients with oral ribavirin and subcutaneous pegylated IFN alpha-2a
demonstrated significant improvement in survival, provided that adequate monitoring and …

… several anti-cytokine antibodies or … IFN-sensitive diseases the proinflammatory cytokines
IL-1 and TNF may play a role in their pathogenesis and antagonism of these cytokines by IFN …

… Interferons may be the most potent and broadly active cytokine family for stimulating cellular
responses to nucleic acids of anomalous structure or location. In response to pathogenic …

… interferon alpha (hIFNα) is a wide biological activity cytokine … human interferon alpha-2b
(hIFNα-2b) as therapeutic protein … (rhIFNα-2b) as therapeutic protein in several types of cancer …