… This complex family regulates both cyto-kine production and cytokine responses in a variety
of rheumatic diseases. Partially overlapping activation signals converge on each kinase …

… The production and release of cytokines from activated cells … psychological factors and
rheumatic disease. Immune mediators … between elevated cytokines with rheumatic disease and …

… diseases is biologic therapy, in which proteins typically bind to cytokines, cell-surface receptors,
or … ; the biologics target a single cytokine or cell receptor; they must be administered by …

… pathogenesis of inflammatory rheumatic diseases, hence the term 'vascular rheumatology'. …
chemokine and its receptor, CXCR4 [29]. In arthritis, proinflammatory cytokines stimulate the …

… or cytokine-stimulated cells that interacts with the receptor for advanced glycosylation end-products
(RAGE). DNA uptake, TLR9 engagement and IFN-α/β production by pDCs are also …

… MIF is now recognized to be a multipotent cytokine involved in the … these diseases. This
paper discusses the function and expressional regulation of MIF in several rheumatic diseases …

… of macrophage activation and secretion of proinflammatory cytokines [83]. … cytokines
generated by activation of these receptors are IL-1β and IL-18. Although both of these cytokines are …

… pathogenesis of autoimmune diseases, including autoimmune rheumatic diseases. In addition
… of numerous cytokines, cytokine receptors, other cell surface receptors and downstream …

IL-6 has been linked to numerous diseases associated with inflammation, including rheumatoid
arthritis, inflammatory bowel disease, vasculitis and several types of cancer. Moreover, IL…

Antigen receptor signaling in lymphocytes has been clearly implicated in the pathogenesis of
the rheumatic diseases. Here, we review evidence from mouse models in which B-cell and …