Can adiponectin help us to target diastolic dysfunction?

C Francisco, JS Neves, I Falcão-Pires… - … drugs and therapy, 2016 - Springer
Atherosclerosis is characterized by chronic systemic inflammation. The first change
preceding the formation of lesions of atherosclerosis is endothelial injury, which is mediated by …

Intercellular communication lessons in heart failure

C Bang, C Antoniades… - European journal of …, 2015 - Wiley Online Library
… communication networks and respective underlying mechanisms which could be involved
in cardiovascular disease conditions and further emphasize promising therapeutic targets for …

Liver X receptors, atherosclerosis and inflammation

DR Michael, TG Ashlin, ML Buckley… - Current atherosclerosis …, 2012 - Springer
atherosclerosis in mouse model systems (see below) and therefore represent promising
therapeutic targets … by factors such as thyroid hormone and certain cytokines [9–11]. Alternative …

Tumor-Associated Macrophages: Therapeutic Targets of Cancer

Y Li, X Zhang, X Zeng, S Wang, H Wang - Macrophage Targeted Delivery …, 2022 - Springer
… The chapter highlighted TAMs as promising therapeutic targets of cancer, which might be …
H 1 cytokines such as INF-γ, M2 type macrophages are induced by the T H 2 cytokines such as …

[HTML][HTML] Diabetic nephropathy: novel molecular mechanisms and therapeutic targets

C Zoja, C Xinaris, D Macconi - Frontiers in Pharmacology, 2020 - frontiersin.org
… Despite these difficulties, experimental models of diabetes have revealed promising therapeutic
targets by identifying pathways that modulate key functions of podocytes and glomerular …

[HTML][HTML] Zinc-dependent histone deacetylases: Potential therapeutic targets for arterial hypertension

HJ Kee, I Kim, MH Jeong - Biochemical Pharmacology, 2022 - Elsevier
… Although the phenotypic analysis of hypertension in isoform HDAC deletion mice is required,
few HDACs (HDAC3, HDAC4, and HDAC8) are promising therapeutic targets for treating …

Mechanisms by which diabetes increases cardiovascular disease

CA Gleissner, E Galkina, JL Nadler, K Ley - Drug Discovery Today …, 2007 - Elsevier
… Increasing prevalence of diabetes and diabetic atherosclerosis … which may represent
promising therapeutic targets. … syndrome seem to represent promising therapeutic targets. This is …

Therapeutic targets in alcohol-associated liver disease: progress and challenges

AD Adekunle, A Adejumo… - Therapeutic Advances in …, 2023 - journals.sagepub.com
… Although there are promising therapeutic targets on the horizon, none of the newer targets is
… proinflammatory cytokines including tumor necrosis factor alpha (TNFα), interleukin 1 (IL1). …

Pathogenic mechanisms following ischemic stroke

SE Khoshnam, W Winlow, M Farzaneh, Y Farbood… - Neurological …, 2017 - Springer
… ischemic stroke and reveal the intertwined pathways that are promising therapeutic targets.
… of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. These cytokines can potentiate …

[HTML][HTML] The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities: A Narrative Review

PK Chen, KT Tang, DY Chen - International Journal of Molecular …, 2024 - mdpi.com
… inflammasome signaling pathway represent promising therapeutic targets, and ongoing …
pro-inflammatory cytokines. MCC950 could reduce macrophage infiltration and atherosclerotic