Sepsis-Associated Acute Kidney Injury: Where Are We Now?

D Kounatidis, NG Vallianou, S Psallida… - Medicina, 2024 - mdpi.com
… also serve as potential therapeutic targets. The combination of … the development of potential
therapeutic targets that could … avoidance of the cytokine storm observed in sepsis. Therefore, …

New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways

B Atto, MS Eapen, P Sharma, U Frey, AJ Ammit… - Clinical …, 2019 - portlandpress.com
Chronic respiratory diseases are among the leading causes of mortality worldwide, with the
major contributor, chronic obstructive pulmonary disease (COPD) accounting for …

Exploring immune checkpoints as potential therapeutic targets in atherosclerosis

PJH Kusters, E Lutgens… - Cardiovascular research, 2018 - academic.oup.com
… Interactions between different immune cells result in the secretion of inflammatory mediators,
such as cytokines and chemokines, and fuel atherogenesis. Immune checkpoint proteins …

circRNA: regulatory factors and potential therapeutic targets in inflammatory dermatoses

R Liu, L Zhang, X Zhao, J Liu, W Chang… - Journal of cellular …, 2022 - Wiley Online Library
… For instance, circRNAs are diagnostic markers and potential therapeutic targets for lung,
breast and colorectal cancers. circRNAs also play a role in the pathological process of various …

Critical illness and the frailty syndrome: mechanisms and potential therapeutic targets

JA Paul, RA Whittington, MR Baldwin - Anesthesia & Analgesia, 2020 - journals.lww.com
… to various inflammatory cytokines and mediators improves … Therefore, monoclonal antibodies
to select cytokines or other … to inflammatory cytokines, the risk of infection was increased …

Identification of potential biomarkers for sepsis based on neutrophil extracellular trap-related genes

J Tang, H Lu, Z Xie, X Jia, T Su, B Lin - Diagnostic Microbiology and …, 2024 - Elsevier
… drugs, providing potential therapeutic targets and treatment strategies for sepsis patients. …
by cytokines in septic patients are linked to high mortality risk [35]. In the pathogenesis of …

A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases

S Pandey, SK Srivastava… - Expert Opinion on …, 2012 - Taylor & Francis
… eliminate the bacterial infection. However, uncontrolled and excessive cytokine expression
can … , thereby, emphasizing the need to identify potential therapeutic targets that may help in …

Anti-inflammatory, anti-oxidative stress and novel therapeutic targets for cholestatic liver injury

Y Zhang, Y Lu, H Ji, Y Li - BioScience Trends, 2019 - jstage.jst.go.jp
… of cholestatic liver disease and find potential therapeutic targets for hepatocyte injury. Many
… the amount of protective cytokine protein produced by Kupffer cells is also decreased. …

Metalloproteinases in rheumatoid arthritis: potential therapeutic targets to improve current therapies

Y Itoh - Progress in molecular biology and translational …, 2017 - Elsevier
cytokines including TNFα, IL-1, IL-6, IL-17, and IFNγ are present in tissue and they contribute
to a chronic state of joint inflammation.1, 2 These inflammatory cytokinescytokines, growth …

Microglial inflammation and phagocytosis in Alzheimer's disease: potential therapeutic targets

S Nizami, H Hall‐Roberts, S Warrier… - British journal of …, 2019 - Wiley Online Library
… All of the AD-linked genes mentioned above that are connected to TREM2 signalling could
be further studied as potential therapeutic targets, as they may be more tractable or provide …