[HTML][HTML] Inflammatory and immune responses in the cochlea: potential therapeutic targets for sensorineural hearing loss

M Fujioka, H Okano, K Ogawa - Frontiers in pharmacology, 2014 - frontiersin.org
cytokines are among the first genes upregulated in response to insults at sites of inflammation.
These cytokines … models of the immune response, infection, ischemia, trauma, cryo-…

[HTML][HTML] Sirtuins as potential therapeutic targets for hepatitis B virus infection

F Kong, Q Li, F Zhang, X Li, H You, X Pan… - Frontiers in …, 2021 - frontiersin.org
Sirtuins (SIRTs) are well-known histone deacetylases that are capable of modulating
various cellular processes in numerous diseases, including the infection of hepatitis B virus (HBV), …

Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis

BS Yuan, RM Zhu, M Braddock, XH Zhang… - Expert opinion on …, 2007 - Taylor & Francis
… evidence suggests that cytokines play a key role in the pathogenesis of local and systemic
complications of acute pancreatitis. IL-18 is a pro-inflammatory cytokine that plays a key role …

Phosphorylation events during viral infections provide potential therapeutic targets

JA Keating, R Striker - Reviews in medical virology, 2012 - Wiley Online Library
For many medically relevant viruses, there is now considerable evidence that both viral and
cellular kinases play important roles in viral infection. Ultimately, these kinases, and the …

[HTML][HTML] Potential Therapeutic Targets for Combination Antibody Therapy against Pseudomonas aeruginosa Infections

LL Proctor, WL Ward, CS Roggy, AG Koontz, KM Clark… - Antibiotics, 2021 - mdpi.com
… This manuscript details the development of potential therapeutic targets for polyclonal
antibody therapies to combat the emergence of multidrug-resistant P. aeruginosa infections. In …

Predictions based on inflammatory cytokine profiling of Egyptian COVID-19 with 2 potential therapeutic effects of certain marine-derived compounds

ME Elnosary, MA Shreadah, ML Ashour… - International …, 2024 - Elsevier
… We are performing an in silico study against two different COVID-19 proteins to investigate
this and highly elevated cytokines, known for their roles in cytokine storms in severe infection

[HTML][HTML] Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets

C Tschoe, CD Bushnell, PW Duncan… - Journal of …, 2020 - ncbi.nlm.nih.gov
… Based on a growing body of evidence, activated microglia appear to be the main source of
cytokines… In order to identify potential therapeutic targets and effectively treat the inflammatory …

Dysregulation of microRNAs in autoimmune diseases: Pathogenesis, biomarkers and potential therapeutic targets

H Long, X Wang, Y Chen, L Wang, M Zhao, Q Lu - Cancer letters, 2018 - Elsevier
infection and trigger a cascade of signal transduction for production of pro-inflammatory and
antiviral cytokines… leads to synthesis of proinflammatory cytokines by inhibiting two negative …

[HTML][HTML] Molecular regulators of resolution of inflammation: potential therapeutic targets in the reproductive system

JL Hutchinson, SP Rajagopal, KJ Sales… - …, 2011 - rep.bioscientifica.com
… Ovulation, menstruation and the onset of labour all feature local production of cytokines, …
stages of inflammation or on the cytokine balance of an established inflammatory environment …

Advancing Sepsis Diagnosis and Immunotherapy Machine Learning-Driven Identification of Stable Molecular Biomarkers and Therapeutic Targets

F Liu, W Xiong, R Xiao, Y Zhan - 2024 - researchsquare.com
… into potential therapeutic targets. The predictive model developed demonstrated high
accuracy in sepsiscytokine levels, thereby improving survival rates and myocardial damage in …