[HTML][HTML] Autophagy: a potential therapeutic target for reversing sepsis-induced immunosuppression

C Ren, H Zhang, T Wu, Y Yao - Frontiers in Immunology, 2017 - frontiersin.org
… pathogens and releasing pro-inflammatory cytokines (58, 59). … potential therapeutic targets
that are concerned with autophagy for reversing immunosuppression compromised by sepsis

Kinases as potential therapeutic targets for anti-coronaviral therapy

T Pillaiyar, S Laufer - Journal of Medicinal Chemistry, 2021 - ACS Publications
… the viral infection cycle (entry, replication, assembly, and egress), and several of them are
involved in the virus-induced hyperinflammatory response that leads to cytokine storm, acute …

Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure

Y Wu, YM Yao, ZQ Lu - Journal of Molecular Medicine, 2019 - Springer
Sepsis is a dysregulated response to severe infection … of sepsis and is associated with poor
outcome of septic patients. … dysfunction are reported in sepsis. Mitochondrial dysfunction with …

Cytokines in Sjögren's syndrome: potential therapeutic targets

N Roescher, PP Tak, GG Illei - Annals of the rheumatic diseases, 2010 - ard.bmj.com
… of cytokines on the most important pathological processes (white ovals) are shown by blue
arrows. The effect of some cytokinesCytokines in the red framed boxes depict cytokines that …

Cytokines: roles in atherosclerosis disease progression and potential therapeutic targets

JWE Moss, DP Ramji - Future medicinal chemistry, 2016 - Future Science
… This review will highlight some of the key cytokines and their roles in the … cytokines as well
as their receptors. A comprehensive coverage of the roles of the full spectrum of cytokines in …

Interleukin 28 is a potential therapeutic target for sepsis

Q Luo, Y Liu, S Liu, Y Yin, B Xu, J Cao - Clinical Immunology, 2019 - Elsevier
… CLP-induced sepsis mortality, while IL-28 administration in sepsis increased mortality. This
study identifies cytokine IL-28 as a new immunotherapeutic agent for the treatment of sepsis. …

Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19: Role of lncRNAs in cytokine storm modulation

A Paniri, H Akhavan-Niaki - Life Sciences, 2020 - Elsevier
… the major cause of inflammatory cytokine storm, and thereby … are implicated in inflammatory
cytokine storm and inflammatory … drugs to target inflammatory cytokines especially IL-6 and …

High-mobility group box-1 isoforms as potential therapeutic targets in sepsis

W Parrish, L Ulloa - Target Discovery and Validation Reviews and …, 2007 - Springer
… extracellular milieu where it functions as a proinflammatory cytokine. Indeed, HMGB1
represents a novel family of inflammatory cytokines composed of intracellular proteins that can be …

[HTML][HTML] Rheumatologists' perspective on coronavirus disease 19 (COVID-19) and potential therapeutic targets

DP Misra, V Agarwal, AY Gasparyan, O Zimba - Clinical rheumatology, 2020 - Springer
… Severe disease in a subset of patients may be driven by cytokine storm, possibly due to …
Cytokine storm and secondary HLH might require heightened immunosuppressive regimens…

Essential functional molecules associated with SARS-CoV-2 infection: Potential therapeutic targets for COVID-19

K Rajarshi, R Khan, MK Singh, T Ranjan, S Ray, S Ray - Gene, 2021 - Elsevier
… syndrome coronavirus 2 (SARS-CoV-2), which are essential for its functionality, survival,
and pathogenesis have been identified and are considered as potential therapeutic targets. …