Critical illness and the frailty syndrome: mechanisms and potential therapeutic targets

JA Paul, RA Whittington, MR Baldwin - Anesthesia & Analgesia, 2020 - journals.lww.com
… to various inflammatory cytokines and mediators improves … Therefore, monoclonal antibodies
to select cytokines or other … to inflammatory cytokines, the risk of infection was increased …

[HTML][HTML] Potential therapeutic targets and vaccine development for SARS-CoV-2/COVID-19 pandemic management: a review on the recent update

U Anand, S Jakhmola, O Indari, HC Jha… - Frontiers in …, 2021 - frontiersin.org
… -19, which denotes the cytokine storm in patients (120). The overall exaggerated immune
response, subsequent cytokine storm, the viral infection leads to the development of acute …

[PDF][PDF] Mechanisms and potential therapeutic targets of hyperinflammatory responses in SARS-CoV-2

IF Chukwuma, VO Apeh, OF Chiletugo - Acta Virol, 2021 - researchgate.net
cytokines known as a cytokine storm. The hallmark of this unregulated inflammatory response
includes viral sepsis, … In the midst of cytokine storm and coagulopathy, anti-viral agents …

[HTML][HTML] Impact of acute kidney injury on distant organ function: recent findings and potential therapeutic targets

K Doi, H Rabb - Kidney international, 2016 - Elsevier
… This review serves to update the topic of organ cross talk in AKI and focuses on potential
therapeutic targets to improve patient outcomes during AKI-associated multiple organ failure. …

Post-cardiac arrest syndrome: pathological processes, biomarkers and vasopressor support, and potential therapeutic targets

SD Mentzelopoulos, SG Zakynthinos - Resuscitation, 2017 - resuscitationjournal.com
… injury, NO overproduction, and cytokine-inhibition of cortisol synthesis). As in septic shock,
standard PCAS treatment includes intravenous fluids and vasopressors/inotropes [ …

Sirtuins: potential therapeutic targets for regulating acute inflammatory response?

V Vachharajani, CE McCall - Expert opinion on therapeutic targets, 2020 - Taylor & Francis
… Adaptive immune cells also increase the expression of many overlapping and cell-specific
cytokines and metabolic pathways [Citation31]. Successful acute inflammation returns to …

The role of ubiquitination in microbial infection induced endothelial dysfunction: potential therapeutic targets for sepsis

J Wang, Y He, D Zhou - Expert Opinion on Therapeutic Targets, 2023 - Taylor & Francis
… many mechanisms of ubiquitination-mediated regulation with a focus on those that modulate
endothelial function to provide potential therapeutic targets for the management of sepsis. …

[图书][B] Host inflammatory pathways in malaria infection: potential therapeutic targets and biomarkers of disease severity

LK Erdman - 2011 - library-archives.canada.ca
… do not stimulate secretion of pro-inflammatory cytokines … does not directly affect PBMC
cytokine responses to malaria … : Regulation of CHI3L1 in murine models of malaria infection

[HTML][HTML] Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets

C Tschoe, CD Bushnell, PW Duncan… - Journal of …, 2020 - ncbi.nlm.nih.gov
… Based on a growing body of evidence, activated microglia appear to be the main source of
cytokines… In order to identify potential therapeutic targets and effectively treat the inflammatory …

[PDF][PDF] Endothelial cells in the decidual bed are potential therapeutic targets for preterm birth prevention

W Deng, J Yuan, J Cha, X Sun, A Bartos, H Yagita… - Cell reports, 2019 - cell.com
… suggest that this cytokine plays a critical role in maintaining a homeostatic balance between
the pro- and anti-inflammatory responses to resist PTB within a certain limit of infection or …