… Characterization of human cytomegalovirus (HCMV) antiviral drug resistance mutations has
contributed to the advancement of HCMV therapy and to knowledge of the basic biological …

… Drug resistant strains of human cytomegalovirus (HCMV) in patients at risk may increasingly
develop into a problem in the clinical setting. Genotypic resistance … newly found mutation. In …

… drug resistance mutations, and the locations of drug … drug resistance mutations, this
technology shows promise for the detection of evolving small subpopulations of resistant mutants…

… developed for the analysis of drug resistance mutations in human cytomegalovirus (CMV). …
pol gene mutations were transferred by recombination into T2211, and their drug resistance …

… Also shown are the locations of the known drug resistance mutations (DRMs) that were
considered in this study and the overlapping amplicons generated during library preparation for …

… UL97 genotyping data; 17 had known resistance mutations (T409M or H411Y) and 5 …
mutation C480F conferred high-grade maribavir resistance and low-grade ganciclovir resistance…

… CMV drug resistance could be a more rapid approach, providing that resistance mutations are
well … Mutations thought to confer drug resistance are confirmed by the genetic technique of …

… resistance. This study significantly increases the number of confirmed CMV pol resistance
mutations, at … for molecular mechanisms and the genotypic diagnosis of antiviral resistance. …

… Many such mutations have now been genetically characterized. Highly resistant or multiply
drugresistant isolates often contain multiple resistance mutations. A limitation of genotypic …

… CMV resistance to foscarnet and ganciclovir was detected after only 6 and 11 weeks of … pol
mutations associated with drug resistance in these patients included T838A (a novel mutation…