Functional importance of the D614G mutation in the SARS-CoV-2 spike protein

CB Jackson, L Zhang, M Farzan, H Choe - Biochemical and Biophysical …, 2021 - Elsevier
… efficient infection of cells and animals by live SARS-CoV-2. This review summarizes and …
D614G spike mutation, with focus on the biochemical and cell-biological impact of this mutation

[HTML][HTML] Spike mutation D614G alters SARS-CoV-2 fitness

JA Plante, Y Liu, J Liu, H Xia, BA Johnson… - Nature, 2021 - nature.com
… spike D614G substitution in the USA-WA1/2020 SARS-CoV-… with SARS-CoV-2 expressing
spike(D614G) (G614 virus) … evidence showing that the mutation enhances viral loads in the …

[HTML][HTML] D614G spike mutation increases SARS CoV-2 susceptibility to neutralization

D Weissman, MG Alameh, T de Silva, P Collini… - Cell host & …, 2021 - cell.com
… respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein acquired a D614G mutation
early in … To determine whether D614G might also mediate neutralization escape that could …

D614G mutation and SARS-CoV-2: impact on S-protein structure, function, infectivity, and immunity

M Bhattacharya, S Chatterjee, AR Sharma… - Applied microbiology …, 2021 - Springer
… of information associated with the D614 mutational occurrence of SARS-CoV-2 variants and
… action of D614G mutant variants, immune escape, and partial vaccine escape of this virus. …

Mutation D614G increases SARS-CoV-2 transmission

P Arora, S Pöhlmann, M Hoffmann - Signal transduction and targeted …, 2021 - nature.com
It has been unclear why SARS-CoV-2 with a D614G mutation … in Science shows that D614G
increases SARS-CoV-2 spread … The causative agent, SARS-CoV-2, is believed to have been …

D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity

J Hu, CL He, QZ Gao, GJ Zhang, XX Cao, QX Long… - BioRxiv, 2020 - biorxiv.org
… Our results also elucidated the cause of increased entry efficiency due to the D614G
mutation in the S protein of SARS-CoV-2. The S-G614 protein contains a novel serine protease …

The virological impacts of SARS-CoV-2 D614G mutation

C Wang, Y Zheng, Z Niu, X Jiang… - Journal of Molecular Cell …, 2021 - academic.oup.com
mutations present in majority of the circulating SARS-CoV-2 … of D614G mutation on the
epidemiology of SARS-CoV-2 and … new insights into future research on SARS-CoV-2 mutations. …

Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide

S Isabel, L Graña-Miraglia, JM Gutierrez… - Scientific reports, 2020 - nature.com
… analysis of over 1,225 SARS-CoV-2 genomes spanning from … missense mutation, D614G,
in the spike protein of SARS-CoV… of D614G on the virulence and epidemiology of SARS-CoV-2…

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

L Zhang, CB Jackson, H Mou, A Ojha, H Peng… - Nature …, 2020 - nature.com
… site with D614G mutation. Therefore, … mutation, D614G, that appears to promote SARS-CoV-2
transmission in humans also enhances functional S-protein incorporation into SARS-CoV-…

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

Z Daniloski, TX Jordan, JK Ilmain, X Guo, G Bhabha… - Elife, 2021 - elifesciences.org
… For temporal tracking of D614G mutations in SARS-CoV-2 genomes, we used the
Nextstrain analysis tool (https://nextstrain.org/ncov) with data obtained from GISAID (https://www.gisaid.…