Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran

J Stangier, M Feuring - Blood coagulation & fibrinolysis, 2012 - journals.lww.com
concentrations of dabigatran using regression analysis. Dabigatran's calibration curve for
thrombin clotting time was … thrombin clotting time in blank samples without dabigatran and in …

… dabigatran concentration, as assessed using the direct thrombin inhibitor assay, and activated clotting time/activated partial thromboplastin time in patients with atrial …

K Okubo, T Kuwahara, K Takagi, M Takigawa… - The American Journal of …, 2015 - Elsevier
dabigatran concentration and the clotting time that is measured using this assay. Although
the relation between clotting time and dabigatran … quantify dabigatran concentrations through …

Measurement of dabigatran plasma concentrations by calibrated thrombin clotting time in comparison to LC-MS/MS in human volunteers on dialysis

M Schmohl, D Gansser, V Moschetti, J Stangier - Thrombosis research, 2015 - Elsevier
… to measure dabigatran concentrations in … dabigatran concentrations within a range of 50–500
ng/ml. The objective of this study was to assess comparability of dabigatran concentrations

… of therapeutic levels of dabigatran in atrial fibrillation evaluated by thrombelastography (TEG®), Hemoclot Thrombin Inhibitor (HTI) assay and Ecarin Clotting Time  …

S Solbeck, AS Jensen, C Maschmann… - … Journal of clinical …, 2018 - Taylor & Francis
dabigatran 110 mg ×2 had a TEG ® R mean 14.2 min (range 9.1–25), a mean dabigatran
concentration … Our data indicate that variation in measured dabigatran concentrations by HTI, …

Impact of dabigatran on a large panel of routine or specific coagulation assays

J Douxfils, F Mullier, S Robert… - Thrombosis and …, 2012 - thieme-connect.com
… The preparation of dabigatran concentrations is presented in Supplementary materials (…
Ratio expressed the clotting time of a NPP spiked with dabigatran divided by the clotting time of …

The effect of dabigatran on the activated partial thromboplastin time and thrombin time as determined by the Hemoclot thrombin inhibitor assay in patient plasma …

G Hapgood, J Butler, E Malan… - Thrombosis and …, 2013 - thieme-connect.com
… (TT) has been shown to be extremely sensitive to the presence of dabigatran but is too
sensitive to quantify concentration (4, 11). The TT is useful in excluding the presence of …

Effect of dabigatran on clotting time in the Clotpro Ecarin clotting assay: a prospective, single-arm, open-label study

AYY Fong, LL Tiong, SSN Tan… - Clinical and Applied …, 2020 - journals.sagepub.com
… The ecarin clotting assay (ECA), performed on the ClotPro viscoelastic … of dabigatran. We
assessed the association between trough plasma dabigatran concentration and clotting time (…

Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis

KH Liesenfeld, HG Schäfer, IF Trocóniz… - British journal of …, 2006 - Wiley Online Library
… The relationship between patient ecarin clotting time (ECT) values and dabigatran plasma
concentrations 0–12 h after first administration of dabigatran etexilate following orthopaedic …

Dabigatran effects on the international normalized ratio, activated partial thromboplastin time, thrombin time, and fibrinogen: a multicenter, in vitro study

WE Dager, RC Gosselin, S Kitchen… - Annals of …, 2012 - journals.sagepub.com
dabigatran concentrations. For the aPTT, all reagents demonstrated decreasing sensitivity to
increasing dabigatran concentrations. … decrease with increasing dabigatran concentrations. …

Measuring dabigatran concentrations using a chromogenic ecarin clotting time assay

RC Gosselin, DM Dwyre… - Annals of …, 2013 - journals.sagepub.com
… to improve sensitivity of the test at lower concentrations (<40 ng/mL) of the drug. We
describe our evaluation of chromogenic ECA for measuring serum dabigatran concentrations. …