Dabigatran etexilate–a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity
J Van Ryn, J Stangier, S Haertter… - Thrombosis and …, 2010 - thieme-connect.com
… of anticoagulant effect. Although there is no specific antidote to antagonise the anticoagulant
… is usually sufficient to reverse any excessive anticoagulant activity. In case of potential …
… is usually sufficient to reverse any excessive anticoagulant activity. In case of potential …
In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate
W Wienen, JM Stassen, H Priepke… - Thrombosis and …, 2007 - thieme-connect.com
… its orally active prodrug,dabigatran etexilate.This study set out to determine the molecular
potency and anticoagulant efficacy of dabigatran and its prodrug dabigatran etexilate.This was …
potency and anticoagulant efficacy of dabigatran and its prodrug dabigatran etexilate.This was …
Comprehensive characteristics of the anticoagulant activity of dabigatran in relation to its plasma concentration
WJ Comuth, LØ Henriksen, D van de Kerkhof… - Thrombosis research, 2018 - Elsevier
… dabigatran anticoagulant activity and liquid chromatography-tandem mass spectrometry (LC-MS/MS)
to measure dabigatran … dabigatran etexilate is unknown. Long-term stability of the …
to measure dabigatran … dabigatran etexilate is unknown. Long-term stability of the …
Laboratory assessment of the anticoagulant activity of dabigatran
E Kyriakou, I Ikonomidis, D Stylos… - Clinical and Applied …, 2015 - journals.sagepub.com
… assess the anticoagulant effects of dabigatran etexilate (DE). … the value of monitoring
dabigatran levels and adjusting the … could be used to assess its anticoagulant activity. Despite the …
dabigatran levels and adjusting the … could be used to assess its anticoagulant activity. Despite the …
Dabigatran/dabigatran etexilate
LA Sorbera, J Bozzo, J Castaner - Drugs of the Future, 2005 - access.portico.org
… HMW Ex vivo anticoagulant activity of BIBR953ZW, a novel synthetic direct thrombin inhibitor
and of its prodrug BIBR1048 MS in different animal species. 18th Cong Int Soc Thromb …
and of its prodrug BIBR1048 MS in different animal species. 18th Cong Int Soc Thromb …
Dabigatran etexilate
M Sanford, GL Plosker - Drugs, 2008 - Springer
… dabigatran etexilate to a parenteral anticoagulant should wait for 24 hours after the last dose
before commencing the parenteral anticoagulant.[… anticoagulants to dabigatran etexilate.[6] …
before commencing the parenteral anticoagulant.[… anticoagulants to dabigatran etexilate.[6] …
The assessment of anticoagulant activity to predict bleeding outcome in atrial fibrillation patients receiving dabigatran etexilate
YT Chang, YF Hu, JN Liao, CM Chern… - Blood Coagulation & …, 2016 - journals.lww.com
… judgments for dabigatran etexilate usage has been … dabigatran etexilate has only been
based on the correlation between the anticoagulant activity in each test and dabigatran etexilate …
based on the correlation between the anticoagulant activity in each test and dabigatran etexilate …
[HTML][HTML] The discovery of dabigatran etexilate
J van Ryn, A Goss, N Hauel, W Wienen… - Frontiers in …, 2013 - frontiersin.org
… clotting time (ECT) is observed at dabigatran concentrations ranging from 0.1 up to 4.6 μM,
… for anticoagulant activity. The thrombin time (TT) assay is extremely sensitive to dabigatran’s …
… for anticoagulant activity. The thrombin time (TT) assay is extremely sensitive to dabigatran’s …
The pharmacology and therapeutic use of dabigatran etexilate
S Sarah - The Journal of Clinical Pharmacology, 2013 - Wiley Online Library
… - a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays
and reversal of anticoagulant activity. Thromb Haemost 2010;103:1116-1127. Used with …
and reversal of anticoagulant activity. Thromb Haemost 2010;103:1116-1127. Used with …
Dabigatran etexilate.
BI Eriksson, H Smith, U Yasothan… - Nature reviews Drug …, 2008 - nature.com
… 1b), which showed strong and long-lasting anticoagulant effects after oral administration in
… the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on …
… the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on …
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