Dabigatran etexilate–a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity

J Van Ryn, J Stangier, S Haertter… - Thrombosis and …, 2010 - thieme-connect.com
… of anticoagulant effect. Although there is no specific antidote to antagonise the anticoagulant
… is usually sufficient to reverse any excessive anticoagulant activity. In case of potential …

In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate

W Wienen, JM Stassen, H Priepke… - Thrombosis and …, 2007 - thieme-connect.com
… its orally active prodrug,dabigatran etexilate.This study set out to determine the molecular
potency and anticoagulant efficacy of dabigatran and its prodrug dabigatran etexilate.This was …

Comprehensive characteristics of the anticoagulant activity of dabigatran in relation to its plasma concentration

WJ Comuth, LØ Henriksen, D van de Kerkhof… - Thrombosis research, 2018 - Elsevier
dabigatran anticoagulant activity and liquid chromatography-tandem mass spectrometry (LC-MS/MS)
to measure dabigatrandabigatran etexilate is unknown. Long-term stability of the …

Laboratory assessment of the anticoagulant activity of dabigatran

E Kyriakou, I Ikonomidis, D Stylos… - Clinical and Applied …, 2015 - journals.sagepub.com
… assess the anticoagulant effects of dabigatran etexilate (DE). … the value of monitoring
dabigatran levels and adjusting the … could be used to assess its anticoagulant activity. Despite the …

Dabigatran/dabigatran etexilate

LA Sorbera, J Bozzo, J Castaner - Drugs of the Future, 2005 - access.portico.org
… HMW Ex vivo anticoagulant activity of BIBR953ZW, a novel synthetic direct thrombin inhibitor
and of its prodrug BIBR1048 MS in different animal species. 18th Cong Int Soc Thromb …

Dabigatran etexilate

M Sanford, GL Plosker - Drugs, 2008 - Springer
dabigatran etexilate to a parenteral anticoagulant should wait for 24 hours after the last dose
before commencing the parenteral anticoagulant.[… anticoagulants to dabigatran etexilate.[6] …

The assessment of anticoagulant activity to predict bleeding outcome in atrial fibrillation patients receiving dabigatran etexilate

YT Chang, YF Hu, JN Liao, CM Chern… - Blood Coagulation & …, 2016 - journals.lww.com
… judgments for dabigatran etexilate usage has been … dabigatran etexilate has only been
based on the correlation between the anticoagulant activity in each test and dabigatran etexilate

[HTML][HTML] The discovery of dabigatran etexilate

J van Ryn, A Goss, N Hauel, W Wienen… - Frontiers in …, 2013 - frontiersin.org
… clotting time (ECT) is observed at dabigatran concentrations ranging from 0.1 up to 4.6 μM,
… for anticoagulant activity. The thrombin time (TT) assay is extremely sensitive to dabigatran’s …

The pharmacology and therapeutic use of dabigatran etexilate

S Sarah - The Journal of Clinical Pharmacology, 2013 - Wiley Online Library
… - a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays
and reversal of anticoagulant activity. Thromb Haemost 2010;103:1116-1127. Used with …

Dabigatran etexilate.

BI Eriksson, H Smith, U Yasothan… - Nature reviews Drug …, 2008 - nature.com
… 1b), which showed strong and long-lasting anticoagulant effects after oral administration in
… the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on …