Pharmacokinetics of quinine in children

F Shann, J Stace, M Edstein - The Journal of pediatrics, 1985 - Elsevier
… l~g/ml quinine, we suggest that children with severe malaria be given a loading dose of 20
mg/kg … followed by intravenous infusions three times a day; quinine dihydrochloride 15 mg/kg …

Quinine Pharmacokinetics and Pharmacodynamics in Children with Malaria Caused by Plasmodium falciparum

M Le Jouan, V Jullien, E Tetanye, A Tran… - Antimicrobial agents …, 2005 - Am Soc Microbiol
… -day quinine treatment given orally to children in Cameroon with malaria caused by Plasmodium
falciparum. Quinine (… formiate salt syrup for 5 days to 30 children (age range, 0.55 to 6.7 …

Treatment of Plasmodium falciparum malaria with quinine in children in Guinea-Bissau: one daily dose is sufficient

PE Kofoed, F Có, A Poulsen, C Cabral… - Transactions of the …, 2002 - Elsevier
… malaria with 1 daily dose of 15 mg quinine salt/kg is sufficient, as the cure rate is not different
from that of treatment with 15 mg/kg or 7.5 mg/kg twice a day and furthermore corresponds …

Population pharmacokinetics of intramuscular quinine in children with severe malaria

S Krishna, NV Nagaraja, T Planche… - Antimicrobial agents …, 2001 - Am Soc Microbiol
children with lactic acidosis due to severe P. falciparum malaria infection. This report
describes the population pharmacokinetics of a loading dose of intramuscular quininequinine

Are one or two dangerous? Quinine and quinidine exposure in toddlers

M Huston, M Levinson - The Journal of emergency medicine, 2006 - Elsevier
… Mild reversible toxicity related to excessive intake (between 1.5 and 4 L daily) of tonic water
… more frequently in children compared to adults after large quinine or quinidine ingestion and …

A trial of artemether or quinine in children with cerebral malaria

MB van Hensbroek, E Onyiorah, S Jaffar… - … England Journal of …, 1996 - Mass Medical Soc
… initial dose of 3.2 mg per kilogram, followed by daily doses of … quinine group received
intramuscular injections of quinine … an initial dose of 20 mg per kilogram, followed by a dose of 10 …

Low-dose quinine for treatment of Plasmodium falciparum malaria in Guinea-Bissau

PE Kofoed, F Lopes, P Johansson, F Dias… - Transactions of the …, 1999 - Elsevier
… The fact that the children in our study who received the highest daily dose of quinine also …
-up might indicate that this was related to the higher dose and thus due to side-effects. We …

Safety and efficacy of rectal compared with intramuscular quinine for the early treatment of moderately severe malaria in children: randomised clinical trial

H Barennes, T Balima-Koussoubé, N Nagot… - Bmj, 2006 - bmj.com
… of rectal quinine (in 19 children by day 5 and in two children by day 14). … quinine occurred
in 40 (8.8%) children, with no subsequent expulsion after administration of half dose quinine

Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: unbound quinine concentrations following a simple loading dose …

PA Winstanley, EK Mberu, WM Watkins… - Transactions of the …, 1994 - Elsevier
… Further- *f more, nurse:patient ratios are often low and a reduction in the number of daily
quinine doses by 50% (ie, 12hourly maintenance rather than g-hourly) offers greater ptacticality …

[HTML][HTML] Shifting from quinine to artesunate as first-line treatment of severe malaria in children and adults: Saving more lives

JJN Noubiap - Journal of infection and public health, 2014 - Elsevier
… of artesunate over quinine in adults and children with severe … day dosage had significantly
lower geometric mean absolute neutrophil counts than did recipients of the 2 and 4 mg/kg/day