Formation of clustered DNA damage after high-LET irradiation: a review
M Hada, AG Georgakilas - Journal of radiation research, 2008 - ieeexplore.ieee.org
… DNA lesions forming a cluster of DNA damage. The two basic groups of complex DNA damage
… This review will focus on the induction of clustered DNA damage by high-LET radiations …
… This review will focus on the induction of clustered DNA damage by high-LET radiations …
Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
A Asaithamby, DJ Chen - Mutation Research/Fundamental and Molecular …, 2011 - Elsevier
… To determine the role of WRN in the processing of complex DNA lesions, we irradiated WS
cells expressing EGFP–WRN with iron particles and found that WRN not only formed foci as …
cells expressing EGFP–WRN with iron particles and found that WRN not only formed foci as …
Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation
BM Sutherland, PV Bennett… - Proceedings of the …, 2000 - National Acad Sciences
… length (L n ) of the resulting DNA population (21). To test our … γ-irradiation of DNA in solution
induced levels of clustered … clustered DNA lesions at significant levels in DNA irradiated …
induced levels of clustered … clustered DNA lesions at significant levels in DNA irradiated …
The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation
N Shikazono, M Noguchi, K Fujii… - Journal of radiation …, 2009 - jstage.jst.go.jp
… , probably because 1) they cause a change of the molecular weight of the irradiated DNA,
which makes them easy to detect, and 2) a great deal of experimental evidence has …
which makes them easy to detect, and 2) a great deal of experimental evidence has …
Radiation-induced clustered DNA lesions: Repair and mutagenesis
E Sage, N Shikazono - Free Radical Biology and Medicine, 2017 - Elsevier
… DNA damage … irradiation lead to clustered DSB and the size of the clusters depended
on the chromatin packing density. The clustering of DSB was most frequent at 5hrs post-irradiation, …
on the chromatin packing density. The clustering of DSB was most frequent at 5hrs post-irradiation, …
Clustered damages and total lesions induced in DNA by ionizing radiation: oxidized bases and strand breaks
BM Sutherland, PV Bennett, O Sidorkina, J Laval - Biochemistry, 2000 - ACS Publications
… DNA at specific classes of damage and electrophoretic assays developed for quantifying
isolated and clustered damages in … For Nfo protein, irradiated DNA was titrated with increasing …
isolated and clustered damages in … For Nfo protein, irradiated DNA was titrated with increasing …
DNA damage clustering after ionizing radiation and consequences in the processing of chromatin breaks
V Mladenova, E Mladenov, M Stuschke, G Iliakis - Molecules, 2022 - mdpi.com
… Accumulated data from atomic force microscopy imaging confirm the induction of clustered
DSBs and the formation of short DNA fragments—even when irradiating “naked” DNA lacking …
DSBs and the formation of short DNA fragments—even when irradiating “naked” DNA lacking …
Induction and repair of clustered DNA lesions: what do we know so far?
AG Georgakilas, P O'Neill… - Radiation research, 2013 - meridian.allenpress.com
… nm) may be capable of producing clusters of oxidative damage (39, 40 ), the … cluster, a
measure of cluster complexity, formed in the DNA of a representative mammalian cell irradiated …
measure of cluster complexity, formed in the DNA of a representative mammalian cell irradiated …
Modeling radiation-induced cell death: role of different levels of DNA damage clustering
MP Carante, S Altieri, S Bortolussi, I Postuma… - Radiation and …, 2015 - Springer
… These authors, applying live cell imaging to X-irradiated MCF10A human cells, found that …
critical DNA cluster damage is still an open question, we chose not to define a priori the cluster …
critical DNA cluster damage is still an open question, we chose not to define a priori the cluster …
Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments. I. Theoretical modeling
WR Holley, A Chatterjee - Radiation research, 1996 - meridian.allenpress.com
… interactions comprise the portion of the modeled irradiation which is simulated explicitly
using Monte Carlo techniques. The contributions to DNA damage yields due to the high-energy …
using Monte Carlo techniques. The contributions to DNA damage yields due to the high-energy …
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