… DNA lesions forming a cluster of DNA damage. The two basic groups of complex DNA damage
… This review will focus on the induction of clustered DNA damage by high-LET radiations …

… To determine the role of WRN in the processing of complex DNA lesions, we irradiated WS
cells expressing EGFP–WRN with iron particles and found that WRN not only formed foci as …

… length (L n ) of the resulting DNA population (21). To test our … γ-irradiation of DNA in solution
induced levels of clustered … clustered DNA lesions at significant levels in DNA irradiated …

… , probably because 1) they cause a change of the molecular weight of the irradiated DNA,
which makes them easy to detect, and 2) a great deal of experimental evidence has …

… DNA damage … irradiation lead to clustered DSB and the size of the clusters depended
on the chromatin packing density. The clustering of DSB was most frequent at 5hrs post-irradiation, …

… DNA at specific classes of damage and electrophoretic assays developed for quantifying
isolated and clustered damages in … For Nfo protein, irradiated DNA was titrated with increasing …

… Accumulated data from atomic force microscopy imaging confirm the induction of clustered
DSBs and the formation of short DNA fragments—even when irradiating “naked” DNA lacking …

… nm) may be capable of producing clusters of oxidative damage (39, 40 ), the … cluster, a
measure of cluster complexity, formed in the DNA of a representative mammalian cell irradiated …

… These authors, applying live cell imaging to X-irradiated MCF10A human cells, found that …
critical DNA cluster damage is still an open question, we chose not to define a priori the cluster …

… interactions comprise the portion of the modeled irradiation which is simulated explicitly
using Monte Carlo techniques. The contributions to DNA damage yields due to the high-energy …