Injectable materials for the treatment of myocardial infarction and heart failure: the promise of decellularized matrices

JM Singelyn, KL Christman - Journal of cardiovascular translational …, 2010 - Springer
matrix or to act as a scaffold for cell delivery. Cardiac-specific decellularized matrices offer
the further advantage of being biomimetic of the native biochemical and structural matrix

Decellularized myocardial matrix hydrogels: In basic research and preclinical studies

RM Wang, KL Christman - Advanced drug delivery reviews, 2016 - Elsevier
… after a myocardial infarction. … of decellularized myocardial matrix hydrogels, methods to
modulate their material properties, demonstrated uses in creating in vitro models of the cardiac

Synergistic effects of adipose-derived stem cells combined with decellularized myocardial matrix on the treatment of myocardial infarction in rats

L Qiao, Y Kong, Y Shi, A Sun, R Ji, C Huang, Y Li… - Life sciences, 2019 - Elsevier
… in the infarct area. Morris et al. [36] found that a mouse skin-derived decellularized matrix
Our results showed that myocardial dECM could increase the expression of angiogenesis-…

… matrix hydrogel containing stromal cell-derived factor 1 promotes transplanted cardiomyocyte engraftment and functional regeneration after myocardial infarction

K Wu, Y Wang, H Yang, Y Chen, K Lu… - … Applied Materials & …, 2023 - ACS Publications
… ) is a hopeful method to treat myocardial infarction (MI). However, its … decellularized porcine
extracellular matrix (dECM) is developed to encapsulate and deliver CMs locally to the infarct

Decellularized extracellular matrix materials for cardiac repair and regeneration

D Bejleri, ME Davis - Advanced healthcare materials, 2019 - Wiley Online Library
… Effects of myocardial matrix hydrogel after myocardial infarction: mechanisms underlying the
functional benefits. Injection of myocardial matrix 1 week after myocardial infarction (MI) into …

Preparation of cardiac extracellular matrix scaffolds by decellularization of human myocardium

B Oberwallner, A Brodarac, YH Choi… - … research Part A, 2014 - Wiley Online Library
… , we extracted DNA from decellularized matrices and controls and measured DNA … who
had suffered from myocardial infarction. In the native state before decellularization, the …

Human versus porcine tissue sourcing for an injectable myocardial matrix hydrogel

TD Johnson, JA DeQuach, R Gaetani… - Biomaterials …, 2014 - pubs.rsc.org
… Heart failure (HF) after myocardial infarction (MI) is a leading cause of death in the western
… an injectable human myocardial matrix (HMM) hydrogel, derived from decellularized human …

Decellularized neonatal cardiac extracellular matrix prevents widespread ventricular remodeling in adult mammals after myocardial infarction

Z Wang, DW Long, Y Huang, WCW Chen, K Kim… - Acta biomaterialia, 2019 - Elsevier
… of different decellularization methods on final biomaterials [37], [55]. The present study utilized
a detergent-free decellularization method in order to preserve bioactivity of the matrix, and …

Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells

KE Sullivan, KP Quinn, KM Tang, I Georgakoudi… - Stem cell research & …, 2014 - Springer
decellularization of diseased tissue allows for the exclusive analysis of the remodeled matrix
… Characterization of cell fate as a function of myocardial remodeling following infarction is …

Injectable decellularized extracellular matrix hydrogel loaded with exosomes encapsulating curcumin for prevention of cardiac fibrosis after myocardial infarction

Y Wang, J Wang, C Liu, J Li, K Lu, Q Yu… - Journal of Materials …, 2023 - Elsevier
Decellularized porcine cardiac extracellular matrix (dECM) … exosomes to the infarcted
myocardium, not only improving the … in infarct size, and an improvement in cardiac function. The …